What compounds affect the RHOQ GTPase cycle pathway?

72 compounds in the BiohacksAI corpus have documented interactions with genes in the RHOQ GTPase cycle pathway (Reactome ID: R-HSA-9013406). These compounds target 7 genes within this pathway.

What genes are in the RHOQ GTPase cycle pathway?

The RHOQ GTPase cycle pathway involves 7 genes. Key genes include: ARHGAP35, CDC42, CDC42BPA, CDC42BPB, CFTR, PAK4, RAB7A.

RHOQ GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-90134067 genes72 compounds

The RHOQ GTPase cycle pathway (Reactome ID: R-HSA-9013406) involves 7 genes and is affected by 72 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARHGAP35 CDC42 CDC42BPA CDC42BPB CFTR PAK4 RAB7A

Compounds Affecting RHOQ GTPase cycle

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	alsterpaullone	—	12
3	Hydrocortisone	—	299
4	Hydrocortisone	—	298
5	Dasatinib	—	299
6	Axitinib	—	298
7	Genistein	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Anisomycin	—	247
10	cycloheximide	—	300
11	Vorinostat	—	299
12	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	Betamethasone	—	299
15	Bumetanide	—	299
16	Chlorthalidone	—	299
17	Ethidium	—	300
18	Cervugid [Supplementary Concept]	—	300
19	Medroxyprogesterone Acetate	—	299
20	Vitamin K 3	—	300
21	Mestranol	—	300
22	Nisoldipine	—	297
23	Quinestrol	—	194
24	Budesonide	—	1,000
25	Methylene Blue	—	200
26	Prednisolone	—	1,000
27	6-Aminonicotinamide	—	300
28	Hyoscyamine	—	296
29	Beclomethasone	—	300
30	Carbazilquinone	—	48
31	Carbidopa	—	298
32	cardamonin	—	180
33	Desoximetasone	—	86
34	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
35	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
36	Digoxin	—	299
37	Dinitrochlorobenzene	—	300
38	Disulfiram	—	297
39	Flumethasone	—	179
40	Fluocinolone Acetonide	—	295
41	Fluorometholone	—	299
42	Flurandrenolone	—	65
43	gamma-Linolenic Acid	—	300
44	Glyburide	—	298
45	Halcinonide	—	88
46	Hexachlorophene	—	300
47	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
48	Medroxyprogesterone	—	298
49	Melengestrol Acetate	—	300
50	Methylprednisolone	—	299

About the RHOQ GTPase cycle Pathway

The RHOQ GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013406) and involves 7 genes. In the BiohacksAI corpus, 72 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, CDC42, CDC42BPA, CDC42BPB, CFTR.