What compounds affect the RHOG GTPase cycle pathway?

31 compounds in the BiohacksAI corpus have documented interactions with genes in the RHOG GTPase cycle pathway (Reactome ID: R-HSA-9013408). These compounds target 8 genes within this pathway.

What genes are in the RHOG GTPase cycle pathway?

The RHOG GTPase cycle pathway involves 8 genes. Key genes include: ARHGAP35, CDC42, EPHA2, HSPE1, PAK4, PIK3R1, RAB7A, SHMT2.

RHOG GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-90134088 genes31 compounds

The RHOG GTPase cycle pathway (Reactome ID: R-HSA-9013408) involves 8 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARHGAP35 CDC42 EPHA2 HSPE1 PAK4 PIK3R1 RAB7A SHMT2

Compounds Affecting RHOG GTPase cycle

#	Compound	Targets Hit	Studies
1	Arachidonic Acid	—	245
2	egcg	—	300
3	plumbagin [Supplementary Concept]	—	300
4	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
5	Adapalene	—	296
6	Aurintricarboxylic Acid	—	184
7	Evans Blue	—	300
8	Hexachlorophene	—	300
9	Lithocholic Acid	—	300
10	rafoxanide	—	172
11	pictilisib	—	25
12	Wortmannin	—	300
13	ly294002	—	11
14	alpelisib	—	227
15	Sirolimus	—	300
16	torin 1	—	10
17	Quercetin	—	300
18	Duloxetine Hydrochloride	—	993
19	Oxaprozin	—	181
20	Papaverine	—	299
21	alsterpaullone	—	12
22	kenpaullone	—	8
23	Axitinib	—	298
24	Sorafenib	—	300
25	Dasatinib	—	299
26	Crizotinib	—	298
27	Hydrocortisone	—	299
28	Hydrocortisone	—	298
29	Guanosine Diphosphate	—	300
30	Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate).	—	300
31	casin	—	10

About the RHOG GTPase cycle Pathway

The RHOG GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013408) and involves 8 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, CDC42, EPHA2, HSPE1, PAK4.