Biosynthesis of aspirin-triggered D-series resolvins

Q: What compounds affect the Biosynthesis of aspirin-triggered D-series resolvins pathway?

39 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of aspirin-triggered D-series resolvins pathway (Reactome ID: R-HSA-9020265). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-90202653 genes39 compounds

The Biosynthesis of aspirin-triggered D-series resolvins pathway (Reactome ID: R-HSA-9020265) involves 3 genes and is affected by 39 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX5 GPX4 LTA4H

Compounds Affecting Biosynthesis of aspirin-triggered D-series resolvins

#	Compound	Targets Hit	Studies
1	Masoprocol	—	300
2	Leukotriene A4 (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid.	—	300
3	amlexanox	—	96
4	cbd	—	298
5	obeticholic acid [Supplementary Concept]	—	271
6	Mepentol [Supplementary Concept]	—	184
7	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
8	Vitamin	—	295
9	Camptothecin	—	300
10	candesartan cilexetil [Supplementary Concept]	—	300
11	cannabidiol	—	296
12	Cefotetan	—	299
13	Cephaloglycin	—	102
14	Cisplatin	—	300
15	Dipyrone	—	298
16	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
17	Ethoxyquin Antioxidant; also	—	180
18	gamma-Linolenic Acid	—	300
19	Gestrinone	—	221
20	Hexachlorophene	—	300
21	Lypressin	—	24
22	Methyldopa	—	297
23	Ornipressin	—	82
24	stx64	—	2
25	Trenbolone Acetate	—	300
26	Triiodothyronine	—	300
27	Quercetin	—	300
28	pterostilbene	—	299
29	piceatannol	—	300
30	butein	—	158
31	Celecoxib	—	295
32	caffeic acid	—	300
33	Kaempferols	—	300
34	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
35	Resveratrol	—	298
36	Anthralin	—	299
37	Bufexamac	—	137
38	Indomethacin	—	297
39	scriptaid	—	53

About the Biosynthesis of aspirin-triggered D-series resolvins Pathway

The Biosynthesis of aspirin-triggered D-series resolvins pathway is catalogued in Reactome (ID: R-HSA-9020265) and involves 3 genes. In the BiohacksAI corpus, 39 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX5, GPX4, LTA4H.