MECP2 regulates transcription of neuronal ligands

Q: What compounds affect the MECP2 regulates transcription of neuronal ligands pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the MECP2 regulates transcription of neuronal ligands pathway (Reactome ID: R-HSA-9022702). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-90227022 genes52 compounds

The MECP2 regulates transcription of neuronal ligands pathway (Reactome ID: R-HSA-9022702) involves 2 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREB1 HDAC1

Compounds Affecting MECP2 regulates transcription of neuronal ligands

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Daunorubicin	—	298
3	cycloheximide	—	300
4	Disulfiram	—	297
5	Azacitidine	—	298
6	Azacitidine	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Levalbuterol	—	1,000
9	Adenosine Monophosphate Adenine nucleotide containing	—	300
10	Levalbuterol	—	297
11	Clofarabine	—	298
12	Dactinomycin	—	297
13	Danazol	—	298
14	Emetine	—	298
15	Ethidium	—	300
16	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
17	Sulbactam	—	299
18	trequinsin hydrochloride	—	1
19	chrysin	—	300
20	Genistein	—	300
21	Quercetin	—	300
22	Testosterone	—	299
23	Ciclopirox	—	88
24	Cladribine	—	297
25	Clenbuterol	—	300
26	Corticosterone	—	300
27	Dasatinib	—	299
28	Dinoprostone	—	296
29	Epinephrine	—	299
30	Ethinyl Estradiol	—	300
31	Imatinib Mesylate	—	300
32	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
33	Nisoldipine	—	297
34	Nocodazole Nocodazole is	—	215
35	Masoprocol	—	300
36	Norepinephrine Precursor of epinephrine that is secreted by	—	298
37	o-Phthalaldehyde	—	300
38	Oxyphenbutazone	—	300
39	pivampicillin	—	275
40	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
41	Salmeterol Xinafoate	—	227
42	Tilorone	—	300
43	Urea	—	297
44	Vorinostat	—	299
45	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
46	scriptaid	—	53
47	Valproic Acid	—	296
48	pictilisib	—	25
49	Butyric Acid	—	300
50	Ursolic Acid	—	300

About the MECP2 regulates transcription of neuronal ligands Pathway

The MECP2 regulates transcription of neuronal ligands pathway is catalogued in Reactome (ID: R-HSA-9022702) and involves 2 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREB1, HDAC1.