What compounds affect the Biosynthesis of E-series 18(R)-resolvins pathway?

58 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of E-series 18(R)-resolvins pathway (Reactome ID: R-HSA-9023661). These compounds target 4 genes within this pathway.

What genes are in the Biosynthesis of E-series 18(R)-resolvins pathway?

The Biosynthesis of E-series 18(R)-resolvins pathway involves 4 genes. Key genes include: ALOX15, ALOX5, GPX4, LTA4H.

Biosynthesis of E-series 18(R)-resolvins

REACTOME PATHWAY

Reactome: R-HSA-90236614 genes58 compounds

The Biosynthesis of E-series 18(R)-resolvins pathway (Reactome ID: R-HSA-9023661) involves 4 genes and is affected by 58 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX15 ALOX5 GPX4 LTA4H

Compounds Affecting Biosynthesis of E-series 18(R)-resolvins

#	Compound	Targets Hit	Studies
1	Masoprocol	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Quercetin	—	300
4	Dipyrone	—	298
5	Celecoxib	—	295
6	Ethoxyquin Antioxidant; also	—	180
7	Hexachlorophene	—	300
8	Leukotriene A4 (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid.	—	300
9	fisetin	—	78
10	Arachidonic Acid	—	245
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	Aurintricarboxylic Acid	—	184
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	Catechin	—	51
15	alpha-Linolenic Acid	—	300
16	brl 50481	—	5
17	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
18	Dactinomycin	—	297
19	dihydroxyflavone	—	256
20	Dihydroxyphenylalanine	—	300
21	Ethidium	—	300
22	ethopropazine hydrochloride	—	2
23	Iodoacetamide	—	300
24	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
25	Linoleic Acid	—	300
26	Procarbazine	—	299
27	Pseudoephedrine	—	298
28	amlexanox	—	96
29	cbd	—	298
30	obeticholic acid [Supplementary Concept]	—	271
31	Mepentol [Supplementary Concept]	—	184
32	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
33	Vitamin	—	295
34	Camptothecin	—	300
35	candesartan cilexetil [Supplementary Concept]	—	300
36	cannabidiol	—	296
37	Cefotetan	—	299
38	Cephaloglycin	—	102
39	Cisplatin	—	300
40	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
41	gamma-Linolenic Acid	—	300
42	Gestrinone	—	221
43	Lypressin	—	24
44	Methyldopa	—	297
45	Ornipressin	—	82
46	stx64	—	2
47	Trenbolone Acetate	—	300
48	Triiodothyronine	—	300
49	pterostilbene	—	299
50	piceatannol	—	300

About the Biosynthesis of E-series 18(R)-resolvins Pathway

The Biosynthesis of E-series 18(R)-resolvins pathway is catalogued in Reactome (ID: R-HSA-9023661) and involves 4 genes. In the BiohacksAI corpus, 58 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX15, ALOX5, GPX4, LTA4H.