What compounds affect the Biosynthesis of DPAn-6 SPMs pathway?

46 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of DPAn-6 SPMs pathway (Reactome ID: R-HSA-9025106). These compounds target 2 genes within this pathway.

What genes are in the Biosynthesis of DPAn-6 SPMs pathway?

The Biosynthesis of DPAn-6 SPMs pathway involves 2 genes. Key genes include: ALOX12, ALOX15.

Biosynthesis of DPAn-6 SPMs

REACTOME PATHWAY

Reactome: R-HSA-90251062 genes46 compounds

The Biosynthesis of DPAn-6 SPMs pathway (Reactome ID: R-HSA-9025106) involves 2 genes and is affected by 46 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX12 ALOX15

Compounds Affecting Biosynthesis of DPAn-6 SPMs

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Masoprocol	—	300
3	fisetin	—	78
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Hexachlorophene	—	300
6	Procarbazine	—	299
7	Dipyrone	—	298
8	ethopropazine hydrochloride	—	2
9	Tyrosine	—	43
10	Tyrosine	—	300
11	butein	—	158
12	celastrol	—	300
13	Chlorhexidine	—	299
14	Ciclopirox	—	88
15	Diiodotyrosine	—	300
16	Disulfiram	—	297
17	Epinephrine	—	299
18	Flecainide	—	297
19	Fomepizole	—	298
20	Gliclazide	—	300
21	isoetharine	—	112
22	Kynurenic Acid	—	300
23	mg624	—	3
24	Phenelzine	—	297
25	piceatannol	—	300
26	Piribedil	—	300
27	Rimonabant	—	300
28	scriptaid	—	53
29	Arachidonic Acid	—	245
30	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
31	Aurintricarboxylic Acid	—	184
32	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
33	Catechin	—	51
34	alpha-Linolenic Acid	—	300
35	brl 50481	—	5
36	Celecoxib	—	295
37	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
38	Dactinomycin	—	297
39	dihydroxyflavone	—	256
40	Dihydroxyphenylalanine	—	300
41	Ethidium	—	300
42	Ethoxyquin Antioxidant; also	—	180
43	Iodoacetamide	—	300
44	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
45	Linoleic Acid	—	300
46	Pseudoephedrine	—	298

About the Biosynthesis of DPAn-6 SPMs Pathway

The Biosynthesis of DPAn-6 SPMs pathway is catalogued in Reactome (ID: R-HSA-9025106) and involves 2 genes. In the BiohacksAI corpus, 46 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX12, ALOX15.