Erythropoietin activates STAT5
REACTOME PATHWAYThe Erythropoietin activates STAT5 pathway (Reactome ID: R-HSA-9027283) involves 3 genes and is affected by 21 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Erythropoietin activates STAT5
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dasatinib | — | 299 |
| 2 | Sorafenib | — | 300 |
| 3 | Azauridine | — | 300 |
| 4 | Cladribine | — | 297 |
| 5 | Methylene Blue | — | 200 |
| 6 | 2-Methoxyestradiol | — | 300 |
| 7 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 8 | Azathioprine | — | 300 |
| 9 | Calcitriol | — | 300 |
| 10 | Camptothecin | — | 300 |
| 11 | Cytarabine | — | 297 |
| 12 | dihydrorotenone | — | 13 |
| 13 | Podophyllotoxin | — | 14 |
| 14 | streptonigrin | — | 299 |
| 15 | Trifluridine | — | 295 |
| 16 | Tripterygium | — | 300 |
| 17 | tyrphostin ag 1478 | — | 4 |
| 18 | alsterpaullone | — | 12 |
| 19 | Crizotinib | — | 298 |
| 20 | kenpaullone | — | 8 |
| 21 | sp600125 | — | 117 |
About the Erythropoietin activates STAT5 Pathway
The Erythropoietin activates STAT5 pathway is catalogued in Reactome (ID: R-HSA-9027283) and involves 3 genes. In the BiohacksAI corpus, 21 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include JAK2, LYN, STAT5A.