What compounds affect the Protein localization pathway?

119 compounds in the BiohacksAI corpus have documented interactions with genes in the Protein localization pathway (Reactome ID: R-HSA-9609507). These compounds target 13 genes within this pathway.

What genes are in the Protein localization pathway?

The Protein localization pathway involves 13 genes. Key genes include: APP, ECH1, EPHX2, FXN, GFER, GSTK1, HSPD1, IDE, IDH1, NOS2.

Protein localization

REACTOME PATHWAY

Reactome: R-HSA-960950713 genes119 compounds

The Protein localization pathway (Reactome ID: R-HSA-9609507) involves 13 genes and is affected by 119 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP ECH1 EPHX2 FXN GFER GSTK1 HSPD1 IDE IDH1 NOS2 PAOX PECR PRNP

Compounds Affecting Protein localization

#	Compound	Targets Hit	Studies
1	Methylene Blue	—	200
2	Hexachlorophene	—	300
3	Disulfiram	—	297
4	Vanillic Acid	—	300
5	Dinitrochlorobenzene	—	300
6	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
7	Anisomycin	—	247
8	Azacitidine	—	298
9	Azacitidine	—	300
10	Chlorhexidine	—	299
11	cycloheximide	—	300
12	Digitoxin	—	300
13	Digoxin	—	299
14	propionylpromazine hydrochloride	—	2
15	streptonigrin	—	299
16	Thioridazine	—	35
17	triflupromazine hydrochloride	—	12
18	Tubercidin	—	300
19	Resveratrol	—	298
20	Arachidonic Acid	—	245
21	caffeic acid	—	300
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	2-Methoxyestradiol	—	300
24	Aurintricarboxylic Acid	—	184
25	Catechin	—	300
26	urolithin b	—	49
27	egcg	—	300
28	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
29	licochalcone	—	267
30	Mometasone Furoate	—	292
31	Lovastatin	—	300
32	Sertraline	—	1,000
33	Simvastatin	—	1,000
34	2-Chloroadenosine 2-Chloroadenosine.	—	300
35	6-Aminonicotinamide	—	300
36	Methotrexate	—	289
37	Astemizole Antihistamine drug now withdrawn from	—	280
38	Azathioprine	—	300
39	Calcimycin	—	216
40	Carbazilquinone	—	48
41	Ciclopirox	—	88
42	clofilium tosylate	—	4
43	colchine	—	2
44	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
45	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
46	Ethinyl Estradiol	—	300
47	Fluspirilene	—	74
48	Imatinib Mesylate	—	300
49	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
50	Miconazole	—	298

About the Protein localization Pathway

The Protein localization pathway is catalogued in Reactome (ID: R-HSA-9609507) and involves 13 genes. In the BiohacksAI corpus, 119 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, ECH1, EPHX2, FXN, GFER.