What genes are in the Infection with Mycobacterium tuberculosis pathway?

The Infection with Mycobacterium tuberculosis pathway involves 8 genes. Key genes include: CTSG, GSK3A, KPNB1, MAPK1, MAPK3, NOS2, RAB7A, TLR2.

Infection with Mycobacterium tuberculosis

Q: What compounds affect the Infection with Mycobacterium tuberculosis pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the Infection with Mycobacterium tuberculosis pathway (Reactome ID: R-HSA-9635486). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-96354868 genes45 compounds

The Infection with Mycobacterium tuberculosis pathway (Reactome ID: R-HSA-9635486) involves 8 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CTSG GSK3A KPNB1 MAPK1 MAPK3 NOS2 RAB7A TLR2

Compounds Affecting Infection with Mycobacterium tuberculosis

#	Compound	Targets Hit	Studies
1	alsterpaullone	—	12
2	kenpaullone	—	8
3	plumbagin [Supplementary Concept]	—	300
4	pd98059	—	7
5	sp600125	—	117
6	fisetin	—	78
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	Sorafenib	—	300
9	trametinib	—	296
10	withaferin	—	300
11	Chlorhexidine	—	299
12	tyrphostin ag 1478	—	4
13	Clotrimazole	—	296
14	Progesterone	—	299
15	2-Chloroadenosine 2-Chloroadenosine.	—	300
16	Benzalkonium Compounds	—	299
17	Calcimycin	—	216
18	daph	—	2
19	Diphenhydramine	—	14
20	ha1004	—	4
21	Lithocholic Acid	—	300
22	Loratadine	—	296
23	trequinsin hydrochloride	—	1
24	indirubin	—	300
25	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	chrysin	—	300
28	Kaempferols	—	300
29	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
30	Quercetin	—	300
31	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
32	piceatannol	—	300
33	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
34	Nitroarginine	—	300
35	Arginine	—	300
36	Arginine	—	300
37	NG-Nitroarginine Methyl Ester	—	238
38	alyssin [Supplementary Concept]	—	300
39	Guanethidine	—	300
40	Reserpine	—	297
41	Guanosine Diphosphate	—	300
42	Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate).	—	300
43	Myristic Acid	—	300
44	Palmitic Acid	—	300
45	Bortezomib	—	300

About the Infection with Mycobacterium tuberculosis Pathway

The Infection with Mycobacterium tuberculosis pathway is catalogued in Reactome (ID: R-HSA-9635486) and involves 8 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CTSG, GSK3A, KPNB1, MAPK1, MAPK3.