What compounds affect the Response of Mtb to phagocytosis pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the Response of Mtb to phagocytosis pathway (Reactome ID: R-HSA-9637690). These compounds target 7 genes within this pathway.

What genes are in the Response of Mtb to phagocytosis pathway?

The Response of Mtb to phagocytosis pathway involves 7 genes. Key genes include: CTSG, GSK3A, KPNB1, MAPK1, MAPK3, NOS2, RAB7A.

Response of Mtb to phagocytosis

REACTOME PATHWAY

Reactome: R-HSA-96376907 genes43 compounds

The Response of Mtb to phagocytosis pathway (Reactome ID: R-HSA-9637690) involves 7 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CTSG GSK3A KPNB1 MAPK1 MAPK3 NOS2 RAB7A

Compounds Affecting Response of Mtb to phagocytosis

#	Compound	Targets Hit	Studies
1	alsterpaullone	—	12
2	kenpaullone	—	8
3	plumbagin [Supplementary Concept]	—	300
4	pd98059	—	7
5	sp600125	—	117
6	fisetin	—	78
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	Sorafenib	—	300
9	trametinib	—	296
10	withaferin	—	300
11	Chlorhexidine	—	299
12	tyrphostin ag 1478	—	4
13	Clotrimazole	—	296
14	Progesterone	—	299
15	2-Chloroadenosine 2-Chloroadenosine.	—	300
16	Benzalkonium Compounds	—	299
17	Calcimycin	—	216
18	daph	—	2
19	Diphenhydramine	—	14
20	ha1004	—	4
21	Lithocholic Acid	—	300
22	Loratadine	—	296
23	trequinsin hydrochloride	—	1
24	indirubin	—	300
25	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	chrysin	—	300
28	Kaempferols	—	300
29	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
30	Quercetin	—	300
31	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
32	piceatannol	—	300
33	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
34	Nitroarginine	—	300
35	Arginine	—	300
36	Arginine	—	300
37	NG-Nitroarginine Methyl Ester	—	238
38	alyssin [Supplementary Concept]	—	300
39	Guanethidine	—	300
40	Reserpine	—	297
41	Guanosine Diphosphate	—	300
42	Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate).	—	300
43	Bortezomib	—	300

About the Response of Mtb to phagocytosis Pathway

The Response of Mtb to phagocytosis pathway is catalogued in Reactome (ID: R-HSA-9637690) and involves 7 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CTSG, GSK3A, KPNB1, MAPK1, MAPK3.