What compounds affect the Signaling by MAP2K mutants pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by MAP2K mutants pathway (Reactome ID: R-HSA-9652169). These compounds target 4 genes within this pathway.

What genes are in the Signaling by MAP2K mutants pathway?

The Signaling by MAP2K mutants pathway involves 4 genes. Key genes include: MAP2K1, MAP2K2, MAPK1, MAPK3.

Signaling by MAP2K mutants

REACTOME PATHWAY

Reactome: R-HSA-96521694 genes26 compounds

The Signaling by MAP2K mutants pathway (Reactome ID: R-HSA-9652169) involves 4 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

MAP2K1 MAP2K2 MAPK1 MAPK3

Compounds Affecting Signaling by MAP2K mutants

#	Compound	Targets Hit	Studies
1	pd98059	—	7
2	trametinib	—	296
3	Sorafenib	—	300
4	plumbagin [Supplementary Concept]	—	300
5	alsterpaullone	—	12
6	kenpaullone	—	8
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	withaferin	—	300
9	Dasatinib	—	299
10	Axitinib	—	298
11	Vemurafenib	—	298
12	tyrphostin ag 1478	—	4
13	Clotrimazole	—	296
14	sp600125	—	117
15	fisetin	—	78
16	Progesterone	—	299
17	2-Chloroadenosine 2-Chloroadenosine.	—	300
18	Benzalkonium Compounds	—	299
19	Calcimycin	—	216
20	daph	—	2
21	Diphenhydramine	—	14
22	ha1004	—	4
23	Lithocholic Acid	—	300
24	Loratadine	—	296
25	trequinsin hydrochloride	—	1
26	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300

About the Signaling by MAP2K mutants Pathway

The Signaling by MAP2K mutants pathway is catalogued in Reactome (ID: R-HSA-9652169) and involves 4 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAP2K1, MAP2K2, MAPK1, MAPK3.