Pexophagy
REACTOME PATHWAYThe Pexophagy pathway (Reactome ID: R-HSA-9664873) involves 4 genes and is affected by 29 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Pexophagy
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | cycloheximide | — | 300 |
| 2 | Emetine | — | 298 |
| 3 | Wortmannin | — | 300 |
| 4 | Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone | — | 76 |
| 5 | Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide. | — | 300 |
| 6 | Topotecan | — | 300 |
| 7 | gedunin | — | 54 |
| 8 | Anisomycin | — | 247 |
| 9 | Bortezomib | — | 300 |
| 10 | Calcimycin | — | 216 |
| 11 | Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. | — | 300 |
| 12 | Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. | — | 300 |
| 13 | Digoxin | — | 299 |
| 14 | Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale, | — | 115 |
| 15 | Oxyphenbutazone | — | 300 |
| 16 | Tubercidin | — | 300 |
| 17 | Gliotoxin | — | 300 |
| 18 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 19 | Quercetin | — | 300 |
| 20 | alpha-Linolenic Acid | — | 300 |
| 21 | salvin [Supplementary Concept] | — | 300 |
| 22 | carnosol | — | 198 |
| 23 | Nigericin | — | 300 |
| 24 | piceatannol | — | 300 |
| 25 | prunetin | — | 35 |
| 26 | withaferin | — | 300 |
| 27 | Methylene Blue | — | 200 |
| 28 | streptonigrin | — | 299 |
| 29 | Novobiocin | — | 300 |
About the Pexophagy Pathway
The Pexophagy pathway is catalogued in Reactome (ID: R-HSA-9664873) and involves 4 genes. In the BiohacksAI corpus, 29 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, EPAS1, MAP1LC3B, USP30.