RND1 GTPase cycle
REACTOME PATHWAYThe RND1 GTPase cycle pathway (Reactome ID: R-HSA-9696273) involves 5 genes and is affected by 16 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RND1 GTPase cycle
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | pictilisib | — | 25 |
| 2 | ly294002 | — | 11 |
| 3 | Sirolimus | — | 300 |
| 4 | Wortmannin | — | 300 |
| 5 | alpelisib | — | 227 |
| 6 | torin 1 | — | 10 |
| 7 | Quercetin | — | 300 |
| 8 | Idarubicin | — | 299 |
| 9 | Aurintricarboxylic Acid | — | 184 |
| 10 | Daunorubicin | — | 298 |
| 11 | Topotecan | — | 300 |
| 12 | Sorafenib | — | 300 |
| 13 | Dasatinib | — | 299 |
| 14 | Crizotinib | — | 298 |
| 15 | Hydrocortisone | — | 299 |
| 16 | Hydrocortisone | — | 298 |
About the RND1 GTPase cycle Pathway
The RND1 GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9696273) and involves 5 genes. In the BiohacksAI corpus, 16 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, CCDC88A, EPHA2, PIK3R1, PIK3R2.