Question 1

What compounds affect the Signaling by FLT3 fusion proteins pathway?

Accepted Answer

21 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by FLT3 fusion proteins pathway (Reactome ID: R-HSA-9703465). These compounds target 5 genes within this pathway.

Question 2

What genes are in the Signaling by FLT3 fusion proteins pathway?

Accepted Answer

The Signaling by FLT3 fusion proteins pathway involves 5 genes. Key genes include: GRB2, NOX4, PIK3R1, PIM1, STAT5A.

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	ly294002	—	11
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Kaempferols	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
7	kenpaullone	—	8
8	sp600125	—	117
9	fisetin	—	78
10	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
11	alsterpaullone	—	12
12	Colchicine	—	300
13	piceatannol	—	300
14	pictilisib	—	25
15	Wortmannin	—	300
16	alpelisib	—	227
17	Sirolimus	—	300
18	torin 1	—	10
19	celastrol	—	300
20	Dactinomycin	—	297
21	Sorafenib	—	300

BiohacksAI

Signaling by FLT3 fusion proteins

Genes in this Pathway

Compounds Affecting Signaling by FLT3 fusion proteins

About the Signaling by FLT3 fusion proteins Pathway