What compounds affect the GABA B receptor activation pathway?

37 compounds in the BiohacksAI corpus have documented interactions with genes in the GABA B receptor activation pathway (Reactome ID: R-HSA-977444). These compounds target 6 genes within this pathway.

What genes are in the GABA B receptor activation pathway?

The GABA B receptor activation pathway involves 6 genes. Key genes include: ADCY9, GABBR1, GABBR2, GNAI1, KCNJ10, KCNJ4.

GABA B receptor activation

REACTOME PATHWAY

Reactome: R-HSA-9774446 genes37 compounds

The GABA B receptor activation pathway (Reactome ID: R-HSA-977444) involves 6 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 GABBR1 GABBR2 GNAI1 KCNJ10 KCNJ4

Compounds Affecting GABA B receptor activation

#	Compound	Targets Hit	Studies
1	Aurintricarboxylic Acid	—	184
2	gamma-Aminobutyric Acid	—	300
3	Daunorubicin	—	298
4	Ethidium	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Rosmarinic Acid	—	300
7	Allantoin	—	300
8	Diiodotyrosine	—	300
9	Dimethylphenylpiperazinium Iodide	—	33
10	Dipyrone	—	298
11	Idarubicin	—	299
12	iodoform	—	272
13	Nicergoline	—	300
14	Pseudoephedrine	—	298
15	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
16	tiopronin	—	299
17	tyrphostin ag 1478	—	4
18	Carmustine	—	297
19	Edaravone	—	298
20	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
21	Iodoacetamide	—	300
22	Cisplatin	—	300
23	Cilostazol	—	297
24	Disulfiram	—	297
25	Physostigmine	—	300
26	Ethylmaleimide	—	300
27	Physostigmine	—	299
28	tyrphostin 1	—	1
29	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
30	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
31	Diamide	—	300
32	Arachidonic Acid	—	245
33	Spermidine	—	241
34	Putrescine	—	300
35	SCH 23390 [Supplementary Concept]	—	126
36	Spermine	—	300
37	Nortriptyline	—	295

About the GABA B receptor activation Pathway

The GABA B receptor activation pathway is catalogued in Reactome (ID: R-HSA-977444) and involves 6 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, GABBR1, GABBR2, GNAI1, KCNJ10.