Regulation of MITF-M-dependent genes involved in apoptosis

Q: What compounds affect the Regulation of MITF-M-dependent genes involved in apoptosis pathway?

53 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of MITF-M-dependent genes involved in apoptosis pathway (Reactome ID: R-HSA-9824594). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98245944 genes53 compounds

The Regulation of MITF-M-dependent genes involved in apoptosis pathway (Reactome ID: R-HSA-9824594) involves 4 genes and is affected by 53 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 BCL2A1 HDAC1 MITF

Compounds Affecting Regulation of MITF-M-dependent genes involved in apoptosis

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	Bortezomib	—	300
3	Camptothecin	—	300
4	pictilisib	—	25
5	Vorinostat	—	299
6	Cefdinir	—	298
7	Ethidium	—	300
8	Oxytetracycline	—	300
9	colchine	—	2
10	Anthralin	—	299
11	Aurintricarboxylic Acid	—	184
12	Biotin	—	297
13	Rolitetracycline	—	166
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	Rutin	—	300
16	cycloheximide	—	300
17	Oxyphenbutazone	—	300
18	Topotecan	—	300
19	Methylene Blue	—	200
20	Rosmarinic Acid	—	300
21	Anisomycin	—	247
22	Astemizole Antihistamine drug now withdrawn from	—	280
23	Azacitidine	—	298
24	Azacitidine	—	300
25	Calcimycin	—	216
26	Carmine Coloring matter from	—	300
27	celastrol	—	300
28	Ciclopirox	—	88
29	clofilium tosylate	—	4
30	Demecolcine	—	246
31	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
32	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
33	Digoxin	—	299
34	Droxidopa	—	202
35	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
36	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
37	Levodopa	—	297
38	Niclosamide	—	299
39	Nocodazole Nocodazole is	—	215
40	Podophyllotoxin	—	14
41	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
42	torin 1	—	10
43	tyrphostin 9	—	2
44	vinblastine sulfate	—	81
45	Vincristine	—	299
46	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
47	scriptaid	—	53
48	Valproic Acid	—	296
49	Butyric Acid	—	300
50	Ursolic Acid	—	300

About the Regulation of MITF-M-dependent genes involved in apoptosis Pathway

The Regulation of MITF-M-dependent genes involved in apoptosis pathway is catalogued in Reactome (ID: R-HSA-9824594) and involves 4 genes. In the BiohacksAI corpus, 53 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, BCL2A1, HDAC1, MITF.