Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence

Q: What compounds affect the Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence pathway?

65 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence pathway (Reactome ID: R-HSA-9825895). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98258953 genes65 compounds

The Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence pathway (Reactome ID: R-HSA-9825895) involves 3 genes and is affected by 65 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRCA1 MITF TERT

Compounds Affecting Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence

#	Compound	Targets Hit	Studies
1	Ethidium	—	300
2	egcg	—	300
3	colchine	—	2
4	cycloheximide	—	300
5	Astemizole Antihistamine drug now withdrawn from	—	280
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Calcimycin	—	216
9	celastrol	—	300
10	Ciclopirox	—	88
11	Demecolcine	—	246
12	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
13	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
14	Niclosamide	—	299
15	Nocodazole Nocodazole is	—	215
16	Podophyllotoxin	—	14
17	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
18	vinblastine sulfate	—	81
19	Cefdinir	—	298
20	Oxytetracycline	—	300
21	Anthralin	—	299
22	Aurintricarboxylic Acid	—	184
23	Biotin	—	297
24	Rolitetracycline	—	166
25	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
26	Rutin	—	300
27	Oxyphenbutazone	—	300
28	Topotecan	—	300
29	Methylene Blue	—	200
30	Rosmarinic Acid	—	300
31	Anisomycin	—	247
32	Bortezomib	—	300
33	Camptothecin	—	300
34	Carmine Coloring matter from	—	300
35	clofilium tosylate	—	4
36	Digoxin	—	299
37	Droxidopa	—	202
38	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
39	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
40	Levodopa	—	297
41	pictilisib	—	25
42	torin 1	—	10
43	tyrphostin 9	—	2
44	Vincristine	—	299
45	Vorinostat	—	299
46	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
47	Resveratrol	—	298
48	Methotrexate	—	289
49	calycosin	—	300
50	Chlorhexidine	—	299

About the Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence Pathway

The Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence pathway is catalogued in Reactome (ID: R-HSA-9825895) and involves 3 genes. In the BiohacksAI corpus, 65 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRCA1, MITF, TERT.