What compounds affect the Kidney development pathway?

48 compounds in the BiohacksAI corpus have documented interactions with genes in the Kidney development pathway (Reactome ID: R-HSA-9830369). These compounds target 5 genes within this pathway.

What genes are in the Kidney development pathway?

The Kidney development pathway involves 5 genes. Key genes include: HNF4A, ID4, PAX8, RET, SIX1.

Kidney development

REACTOME PATHWAY

Reactome: R-HSA-98303695 genes48 compounds

The Kidney development pathway (Reactome ID: R-HSA-9830369) involves 5 genes and is affected by 48 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HNF4A ID4 PAX8 RET SIX1

Compounds Affecting Kidney development

#	Compound	Targets Hit	Studies
1	gedunin	—	54
2	Chlorhexidine	—	299
3	Demecolcine	—	246
4	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
5	Anisomycin	—	247
6	Colchicine	—	300
7	colchine	—	2
8	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
9	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
10	Digoxin	—	299
11	Hexachlorophene	—	300
12	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
13	Podophyllotoxin	—	14
14	vinblastine sulfate	—	81
15	Vorinostat	—	299
16	2-Chloroadenosine 2-Chloroadenosine.	—	300
17	Astemizole Antihistamine drug now withdrawn from	—	280
18	Calcimycin	—	216
19	Ciclopirox	—	88
20	clofilium tosylate	—	4
21	Decitabine	—	298
22	Ethidium	—	300
23	mg624	—	3
24	Nocodazole Nocodazole is	—	215
25	torin 1	—	10
26	tyrphostin 9	—	2
27	Progesterone	—	299
28	hydroxyindoleacetic acid	—	300
29	Linoleic Acid	—	300
30	Nisoldipine	—	297
31	Oxyphenbutazone	—	300
32	Triiodothyronine	—	300
33	Wortmannin	—	300
34	Sorafenib	—	300
35	Axitinib	—	298
36	Dasatinib	—	299
37	Crizotinib	—	298
38	Nortriptyline	—	295
39	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
40	sp600125	—	117
41	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
42	Methylene Blue	—	200
43	Cefdinir	—	298
44	Fusaric Acid	—	300
45	Indapamide	—	299
46	alpha-Linolenic Acid	—	300
47	Dehydrocholic Acid	—	203
48	Practolol	—	300

About the Kidney development Pathway

The Kidney development pathway is catalogued in Reactome (ID: R-HSA-9830369) and involves 5 genes. In the BiohacksAI corpus, 48 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HNF4A, ID4, PAX8, RET, SIX1.