Question 1

What compounds affect the Dengue Virus Genome Translation and Replication pathway?

Accepted Answer

37 compounds in the BiohacksAI corpus have documented interactions with genes in the Dengue Virus Genome Translation and Replication pathway (Reactome ID: R-HSA-9918487). These compounds target 16 genes within this pathway.

Question 2

What genes are in the Dengue Virus Genome Translation and Replication pathway?

Accepted Answer

The Dengue Virus Genome Translation and Replication pathway involves 16 genes. Key genes include: EIF4A1, EIF4G1, FASN, HSPA1A, HSPA1B, HSPA5, HSPA8, KPNB1, MAP1LC3B, P4HB.

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
3	Oxytetracycline	—	300
4	Ergosterol	—	300
5	egcg	—	300
6	Cefixime	—	300
7	Adenosine Triphosphate	—	300
8	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
9	Oxcarbazepine	—	296
10	Rosmarinic Acid	—	300
11	Rutin	—	300
12	Anthralin	—	299
13	Ethidium	—	300
14	Phenoxybenzamine	—	21
15	sp600125	—	117
16	Temozolomide	—	299
17	DEAD-box RNA Helicases	—	169
18	Thioctic Acid	—	298
19	Thioctic Acid	—	300
20	Azauridine	—	300
21	Levetiracetam	—	296
22	Cerulenin	—	300
23	Dihydroergotoxine	—	208
24	Oleic Acid	—	112
25	gedunin	—	54
26	Clotrimazole	—	296
27	Demeclocycline	—	5
28	Edaravone	—	298
29	Cefdinir	—	298
30	plumbagin [Supplementary Concept]	—	300
31	oridonin	—	300
32	cycloheximide	—	300
33	Chlorhexidine	—	299
34	Reserpine	—	297
35	Equilin	—	216
36	Calcifediol	—	300
37	Novobiocin	—	300

BiohacksAI

Dengue Virus Genome Translation and Replication

Genes in this Pathway

Compounds Affecting Dengue Virus Genome Translation and Replication

About the Dengue Virus Genome Translation and Replication Pathway