What genes are in the SLC-mediated transport of organic anions pathway?

The SLC-mediated transport of organic anions pathway involves 15 genes. Key genes include: SLC17A5, SLC22A11, SLC22A12, SLC22A6, SLC22A7, SLC22A8, SLC5A7, SLCO1A2, SLCO1B1, SLCO1B3.

SLC-mediated transport of organic anions

Q: What compounds affect the SLC-mediated transport of organic anions pathway?

86 compounds in the BiohacksAI corpus have documented interactions with genes in the SLC-mediated transport of organic anions pathway (Reactome ID: R-HSA-9955298). These compounds target 15 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-995529815 genes86 compounds

The SLC-mediated transport of organic anions pathway (Reactome ID: R-HSA-9955298) involves 15 genes and is affected by 86 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SLC17A5 SLC22A11 SLC22A12 SLC22A6 SLC22A7 SLC22A8 SLC5A7 SLCO1A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1

Compounds Affecting SLC-mediated transport of organic anions

#	Compound	Targets Hit	Studies
1	Dinoprost	—	252
2	Dinoprostone	—	296
3	Triiodothyronine	—	300
4	Rifamycins	—	300
5	Rifamycins	—	300
6	Thyroxine	—	994
7	Thyroxine	—	300
8	Cefamandole Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as	—	300
9	Cefazolin	—	300
10	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	—	300
11	cefotaxime	—	299
12	Ceftriaxone	—	299
13	Cephaloridine	—	300
14	Indomethacin	—	297
15	Ritonavir	—	298
16	Atorvastatin	—	1,000
17	Genistein	—	300
18	Glyburide	—	298
19	Silymarin	—	10
20	Probenecid	—	298
21	Dicloxacillin	—	297
22	cefadroxil	—	299
23	Thioctic Acid	—	182
24	piperacillin	—	298
25	Bilirubin	—	296
26	Pravastatin	—	297
27	Arachidonic Acid	—	245
28	Losartan	—	1,000
29	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
30	beta Carotene	—	299
31	candesartan cilexetil [Supplementary Concept]	—	300
32	Gemfibrozil	—	297
33	Mometasone Furoate	—	292
34	Olmesartan Medoxomil	—	300
35	Antimycin	—	300
36	Digoxin	—	299
37	Taurocholic Acid	—	300
38	Alprostadil	—	297
39	Dehydroepiandrosterone Sulfate	—	300
40	Oxacillin	—	298
41	Penicillin G	—	298
42	Carnitine	—	300
43	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
44	Azlocillin	—	300
45	cefaclor	—	299
46	Cefoxitin	—	300
47	Cloxacillin	—	299
48	Methicillin	—	299
49	Nafcillin	—	297
50	Penicillin V	—	300

About the SLC-mediated transport of organic anions Pathway

The SLC-mediated transport of organic anions pathway is catalogued in Reactome (ID: R-HSA-9955298) and involves 15 genes. In the BiohacksAI corpus, 86 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SLC17A5, SLC22A11, SLC22A12, SLC22A6, SLC22A7.