What compounds target PGR?

BiohacksAI has identified 189 compounds that interact with PGR (progesterone receptor). Top compounds include: Progesterone, Medroxyprogesterone Acetate, Levonorgestrel, Norethindrone, Norgestrel. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PGR (progesterone receptor)?

PGR is progesterone receptor. It is a molecular target for 189 compounds documented in PubMed bioassay data. UniProt ID: P06401. NCBI Gene ID: 5241.

PGR

MOLECULAR TARGET

progesterone receptor

UniProt: P06401 NCBI Gene: 5241189 compounds

PGR (progesterone receptor) is targeted by 189 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PGR

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Progesterone	3.99	53
2	Medroxyprogesterone Acetate	3.47	31
3	Levonorgestrel	2.30	9
4	Norethindrone	2.30	9
5	Norgestrel	2.30	9
6	Spironolactone	2.20	8
7	Budesonide	2.08	7
8	Triamcinolone Acetonide	2.08	7
9	Genistein	1.95	6
10	Resveratrol	1.95	6
11	Danazol	1.95	6
12	Dihydrotestosterone	1.95	6
13	Mestranol	1.95	6
14	Methylprednisolone	1.95	6
15	Rotenone	1.95	6
16	Hydrocortisone	1.79	5
17	Betamethasone	1.79	5
18	Ethinyl Estradiol	1.79	5
19	Fluorometholone	1.79	5
20	Flurandrenolone	1.79	5
21	Fulvestrant	1.79	5
22	Hydrocortisone	1.79	5
23	Testosterone Propionate	1.79	5
24	Prednisolone	1.61	4
25	Quercetin	1.61	4
26	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.61	4
27	Carbaryl	1.61	4
28	Corticosterone	1.61	4
29	Dactinomycin	1.61	4
30	Dydrogesterone	1.61	4
31	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	1.61	4
32	Estrone	1.61	4
33	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	1.61	4
34	Ethynodiol Diacetate	1.61	4
35	Flutamide	1.61	4
36	Lynestrenol	1.61	4
37	Megestrol Acetate Megestrol acetate is	1.61	4
38	Mometasone Furoate	1.61	4
39	Nisoldipine	1.61	4
40	Troglitazone	1.61	4
41	Apigenin 5,7,4'-trihydroxy-flavone,	1.39	3
42	Dehydroepiandrosterone	1.39	3
43	Kaempferols	1.39	3
44	17-alpha-Hydroxyprogesterone	1.39	3
45	Azacitidine	1.39	3
46	Azacitidine	1.39	3
47	Beclomethasone	1.39	3
48	Betamethasone Valerate	1.39	3
49	Canrenone	1.39	3
50	Chlormadinone Acetate	1.39	3

Showing top 50 of 189 compounds. Use the BiohacksAI search to explore all PGR modulators.

About PGR as a Drug Target

PGR (progesterone receptor) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 189 compounds with documented PGR interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PGR inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.