What compounds target SMAD3?

BiohacksAI has identified 63 compounds that interact with SMAD3 (SMAD family member 3). Top compounds include: Calcimycin, cycloheximide, alsterpaullone, Anisomycin, Azacitidine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SMAD3 (SMAD family member)?

SMAD3 is SMAD family member 3. It is a molecular target for 63 compounds documented in PubMed bioassay data. UniProt ID: P84022. NCBI Gene ID: 4088.

SMAD3

MOLECULAR TARGET

SMAD family member 3

UniProt: P84022 NCBI Gene: 408863 compounds

SMAD3 (SMAD family member 3) is targeted by 63 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SMAD3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Calcimycin	1.61	4
2	cycloheximide	1.61	4
3	alsterpaullone	1.39	3
4	Anisomycin	1.39	3
5	Azacitidine	1.39	3
6	Azacitidine	1.39	3
7	Disulfiram	1.39	3
8	kenpaullone	1.39	3
9	Nisoldipine	1.39	3
10	Tubercidin	1.39	3
11	Apigenin 5,7,4'-trihydroxy-flavone,	1.10	2
12	Kaempferols	1.10	2
13	Quercetin	1.10	2
14	cardamonin	1.10	2
15	Colchicine	1.10	2
16	Dactinomycin	1.10	2
17	Danazol	1.10	2
18	Dasatinib	1.10	2
19	Dinitrochlorobenzene	1.10	2
20	Ethidium	1.10	2
21	Flutamide	1.10	2
22	Loratadine	1.10	2
23	Oxyphenbutazone	1.10	2
24	Podophyllotoxin	1.10	2
25	vinblastine sulfate	1.10	2
26	Vincristine	1.10	2
27	chrysin	0.69	1
28	egcg	0.69	1
29	Fluoxetine	0.69	1
30	Methylene Blue	0.69	1
31	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	0.69	1
32	Astemizole Antihistamine drug now withdrawn from	0.69	1
33	Bortezomib	0.69	1
34	Celecoxib	0.69	1
35	Ciclopirox	0.69	1
36	Cladribine	0.69	1
37	Daunorubicin	0.69	1
38	Digitoxin	0.69	1
39	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	0.69	1
40	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	0.69	1
41	Domperidone	0.69	1
42	Emetine	0.69	1
43	Equilin	0.69	1
44	Ethinyl Estradiol	0.69	1
45	Ezetimibe	0.69	1
46	Fluspirilene	0.69	1
47	Hexachlorophene	0.69	1
48	Idazoxan	0.69	1
49	Lynestrenol	0.69	1
50	Nocodazole Nocodazole is	0.69	1

Showing top 50 of 63 compounds. Use the BiohacksAI search to explore all SMAD3 modulators.

About SMAD3 as a Drug Target

SMAD3 (SMAD family member 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 63 compounds with documented SMAD3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SMAD3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.