How BiohacksAI works
BiohacksAI is an AI-driven compound research and discovery platform built on 1.14 million PubMed studies, a deterministic graph of 31,590 substances, and a cryptographic evidence chain called X-Vault.
The platform does two things: it lets researchers query the scientific literature with evidence-grade answers, and it systematically discovers novel compound–pathway combinations that may have research value.
The evidence layer
Every claim in BiohacksAI is backed by a specific PubMed study. The corpus is a curated, versioned snapshot of PubMed abstracts indexed by substance, target, pathway, and study type.
The corpus is locked at a specific version — currently v20260312-01. When you query the system you always get an answer from the same dataset, and every answer includes a Merkle root hash that proves which version was used.
How discoveries are generated
The discovery engine scans the corpus for compounds that have strong biological target coverage but low literature footprint — meaning the scientific community has not yet fully characterised them.
These candidates are ranked by a two-layer scoring system and sealed cryptographically into the X-Vault evidence chain.
Discovery score and access tiers
Every compound is evaluated by two complementary scores. The discovery score measures biological breadth. The biotech score measures research relevance against known drug targets.
Compounds with many validated targets, broad pathway coverage, and low literature footprint score highest. The log-damping on studies ensures that well-studied compounds are de-prioritised in favour of understudied ones.
Target relevance is a weighted sum based on the HIGH_VALUE_TARGETS registry — 60+ gene symbols classified as Tier 3 (kinases, transcription factors, metabolic regulators: EGFR, NFE2L2, MTOR, SIRT1, TP53, BRD4, JAK1…) or Tier 2 (research-grade: MAPK1, SOD1, APP, HDAC2…).
- ✓ All compound profiles
- ✓ Target + pathway pages
- ✓ BiohackerPanel
- ✓ Stack Lab (hypothesis)
- ✓ Ayurveda search
- — Discoveries marketplace
- — API access
- ✓ Everything in Explorer
- ✓ Discoveries marketplace
- ✓ White Space analysis
- ✓ Knowledge graph
- ✓ Export (CSV / JSON)
- ✓ API — 1,000 req/day
- — Full API
- ✓ Everything in Researcher
- ✓ Full API — unlimited
- ✓ Discovery report access
- ✓ Bulk compound queries
- ✓ Webhook on new discoveries
- ✓ Corpus version pinning
- ✓ Priority support
Pricing and availability will be announced. Join the waitlist: info@eveverified.com
Cryptographic evidence sealing
Every discovery is sealed into the X-Vault — an append-only, SHA-256 hash-chained log that provides a cryptographically verifiable record of when a discovery was made and what corpus version it was based on.
The X-Vault WORM log is stored server-side and is never rewritten — only appended to. Anyone can independently verify a discovery at biohacksai.com/verify.
Visualising how a compound works
Every discovery includes a mechanism discovery graph — a force-directed visualisation showing the relationship between the compound, its molecular targets, and the biological pathways those targets regulate.
Fixed at centre. The compound being analysed.
The gene/protein targets the compound interacts with. Colour-coded by research relevance: gold = Tier 3 (kinases and TFs), indigo = Tier 2 (research targets), teal = standard. A pulsing dashed ring marks Tier 3 targets with ≤ 5 studies — the knowledge gap indicator.
The biological systems those targets belong to (Reactome). Shown as dashed rectangles connected by dotted lines from their associated targets.
Discovery reports
Sealed discoveries are listed in the marketplace. Each entry shows the compound, mechanism pathway, discovery score, and X-Vault seal. Contact us to request access to the full report.
AI proposes. Humans decide.
BiohacksAI is built on the EVE (Evidence & Verification Engine) architecture developed by Organiq Sweden AB. The core principle is witness mode: the AI generates hypotheses and surfaces evidence, but all decisions are made by humans and recorded with human-controlled cryptographic keys.
- — The discovery engine never licenses anything autonomously
- — Every discovery seal requires a verified admin key
- — The system logs what it proposed and when — the human logs what they decided
- — No discovery can be unsealed or retroactively altered
All discoveries are labelled as computational hypothesis candidates — not confirmed mechanisms. Independent experimental validation is always required.
Verify any discovery
Anyone can verify a discovery — no account required. Paste a Discovery ID or event hash into the verification page. The system walks the X-Vault chain and confirms whether the discovery exists and whether the chain integrity is intact.
The platform that grows while you sleep
Most research databases are static — they reflect the world as it was when someone last updated them. BiohacksAI is different. Every Sunday at 03:00 UTC, the compound discovery engine runs autonomously: scanning PubMed, extracting candidates, validating against PubChem, and promoting new substances into the evidence corpus — all without human intervention.
Sources & licenses
BiohacksAI is built on publicly available scientific databases. We are grateful to the teams behind these resources.
Data is used for non-commercial research and hypothesis generation. Bioactivity records from ChEMBL and BindingDB are aggregated and scored; individual assay records are not redistributed. Natural product data from COCONUT is used for compound identification only. If you believe any usage conflicts with a source license, contact info@eveverified.com.
BiohacksAI is currently in active development and open to early access. The platform will be locked to approved users when we launch — sign up now to secure a spot.
Demo licence — Email info@eveverified.com to request early access.
Become a development partner — Interested in co-developing BiohacksAI or joining as an early partner? We are open to conversations with researchers, institutions, and investors. Reach out at info@eveverified.com.