HYPOTHESIS_ENGINE_v1.0
Mechanism Gap Analysis
Enter any compound. Discover which substances cover the biological pathway targets it misses — automatically.
Popular compounds
How it works
1
Map known targets — Identifies all gene targets the compound modulates via PubChem bioassay data
2
Find pathway context — Locates relevant Reactome pathways using target overlap (≥2 hits, ≤150 genes)
3
Detect missing targets — Computes pathway genes the compound does not directly hit
4
Score candidates — Ranks gap-filling compounds by IDF × evidence × rarity × momentum
Deterministic graph-traversal. No AI interpretation. Results are reproducible and corpus-bound.