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Compounds Studied for Longevity Pathways
Longevity research focuses on pathways such as AMPK, mTOR, sirtuins, and cellular repair mechanisms. Published research has documented compounds in relation to NAD+ metabolism, senescent cell biology, autophagy, and telomere-associated targets.
Top 10 Compounds — Ranked by Evidence
Weighted ranking: BiohacksAI discovery score · pathway overlap · PubMed study count
1
Alpha Ketoglutaratefeatured
195+
studies
2
Astaxanthinfeatured
300+
studies
3
Berberinefeatured
300+
studies
4
Fisetinfeatured
78+
studies
5
Nmnfeatured
300+
studies
6
Pterostilbenefeatured
299+
studies
7
Quercetinfeatured
300+
studies
8
Rapamycinfeatured
300+
studies
9
Resveratrolfeatured
298+
studies
10
Spermidinefeatured
241+
studies
Ranking Methodology
Compounds are ranked using a four-signal weighted model: BiohacksAI discovery score (cross-study convergence across targets), target match (direct overlap with SIRT1, MTOR, PRKAA1 and related targets — highest differentiating signal), pathway overlap with goal-relevant pathways, and PubMed study count (log-scaled). Clinical drugs are excluded.
Key Molecular Targets
Related Conditions
Related Research Domains
Rankings based on BiohacksAI discovery score, pathway overlap, and PubMed study count. All data is deterministic and corpus-verified. Not medical advice.
Browse all compounds · Biological pathways · Molecular targets · Health conditions
Data: PubMed/NCBI, BindingDB, Reactome. © Organiq Sweden AB · Patent pending EVE-PAT-2026-001