BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.

BiohacksAI is an evolving scientific literature platform. New compounds and evidence are indexed continuously.

Evidence-Based Research Platform

Patent Pending

○

OPRD Modulators

COMPOUND CLUSTER

288 compoundscohesion 0.840cluster #6

The OPRD Modulators cluster contains 288 compounds grouped by shared molecular target interactions, computed via Louvain community detection on the BiohacksAI target interaction graph.

Compounds in this Cluster

bdb chebi 3216 buprenorphine7 studies bdb chembl42836812 studies bdb nsc 223652 cas 29485 83 4 codeine codeine sulfate4 studies bdb 1n 10 hydroxy 4 methyl 14 oxo 13r 17s 12 oxa 4 azapentacyclo 9 6 1 01 13 05 17 03 studies bdb naloxone nsc 10064 cas 465 65 6 naloxone4 studies bdb cas 115077 nsc 115077 win 44 4413 studies bdb mcl 183 chembl3908663 studies bdb chembl378753 nalbzoh3 studies bdb cas 27943 naltrexone hcl nsc 27943 naltrexone3 studies bdb buprenorphine buprenorphine2 3 cyclopropylmethyl 11 hydroxy 15 methoxy 13 oxa 3 3 studies bdb chembl79470 mr 2034 6 11 dimethyl 3 tetrahydro furan 2 ylmethyl 1 2 3 4 5 6 hexa3 studies bdb chembl21136663 studies bdb cas 105618 26 6 nsc 3034416 nor bni3 studies bdb chembl48718802 studies bdb chembl48462432 studies bdb chembl46367992 studies bdb chembl45142262 studies bdb chembl44634142 studies bdb chembl46386932 studies bdb chembl45776932 studies bdb chembl44380462 studies bdb chembl44595922 studies bdb chembl46497332 studies bdb chembl42428472 studies bdb chembl42434632 studies bdb chembl42111132 studies bdb chembl42037532 studies bdb chembl42431122 studies bdb chembl42488012 studies bdb chembl42410312 studies bdb chembl42383092 studies bdb chembl42133512 studies bdb chembl42392402 studies bdb chembl42404262 studies bdb chembl42459872 studies bdb ekc chembl55033 3 cyclopropylmethyl 6 ethyl 8 hydroxy 11 methyl 3 4 5 6 tetrahyd2 studies bdb chembl42492562 studies bdb chembl42377582 studies bdb chembl42413692 studies bdb chembl42436492 studies bdb chembl42378542 studies bdb chembl42464332 studies bdb chembl42458182 studies bdb chembl42382892 studies bdb chembl41688222 studies bdb chembl42182842 studies bdb chembl42133362 studies bdb chembl42101812 studies bdb chembl20593822 studies bdb chembl40766812 studies bdb chembl40766322 studies bdb chembl40921192 studies bdb chembl41009432 studies bdb chembl40686912 studies bdb chembl40891932 studies bdb chembl40818562 studies bdb chembl40986622 studies bdb chembl40702772 studies bdb chembl40839402 studies bdb chembl40839112 studies bdb chembl40810532 studies bdb chembl40735372 studies bdb chembl40676292 studies bdb chembl20593812 studies bdb chembl40948452 studies bdb chembl40713242 studies bdb chembl40667522 studies bdb chembl40903652 studies bdb chembl41030442 studies bdb chembl40941702 studies bdb chembl40618822 studies bdb chembl41053062 studies bdb chembl40613342 studies bdb chembl6073512 studies bdb chembl40809142 studies bdb chembl40713622 studies bdb chembl40665352 studies bdb chembl4062717 us10377763 example 342 studies bdb 1 adamantan 1 yl 3 2 2 amino 3 4 hydroxy 2 6 dimethyl phenyl propionyl 1 2 3 4 t2 studies bdb cas 24822798 nsc 24822798 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb chembl21132972 studies bdb 1s 9r 10r 5 amino 20 cyclobutylmethyl 6 thia 4 20 diazapentacyclo 8 7 3 0 1 9 0 2 studies bdb chembl21116082 studies bdb chembl21133012 studies bdb chembl21132952 studies bdb 7 19 dimethyl 11 oxa 6 8 19 triazahexacyclo 10 9 1 01 10 02 18 04 9 016 22 docos2 studies bdb chembl21132962 studies bdb chembl21124072 studies bdb chembl21132992 studies bdb chembl21133032 studies bdb chembl21133102 studies bdb chembl37869702 studies bdb chembl33095122 studies bdb chembl21133072 studies bdb chembl33095102 studies bdb chembl11695832 studies bdb chembl30863062 studies bdb chembl21128442 studies bdb chembl21133772 studies bdb chembl21133062 studies bdb chembl21133082 studies bdb chembl33095132 studies bdb cas 24822630 nsc 24822630 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb chembl33095112 studies bdb chembl21133822 studies bdb chembl32912162 studies bdb chembl21133052 studies bdb chembl21132982 studies bdb chembl21132812 studies bdb nsc 24822297 cas 24822297 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb chembl21133112 studies bdb nsc 24824637 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epoxy 6 alpha be2 studies bdb chembl21133122 studies bdb chembl21136722 studies bdb chembl33579672 studies bdb chembl3262093 us9480684 13b r ph bu125 us9259422 13b r ph bu1252 studies bdb nsc 24822802 cas 24822802 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb nsc 24824635 cas 24824635 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb chembl32912142 studies bdb chembl33579662 studies bdb chembl30863072 studies bdb chembl30863032 studies bdb chembl21123742 studies bdb cas 24822801 nsc 24822801 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb chembl21128432 studies bdb chembl32912152 studies bdb chembl37852652 studies bdb chembl21136712 studies bdb chembl21132942 studies bdb sj000091719 chembl21133002 studies bdb chembl21133042 studies bdb chembl33095062 studies bdb chembl33095082 studies bdb chembl21133782 studies bdb chembl21132752 studies bdb chembl21133832 studies bdb nsc 24822632 cas 24822632 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb chembl33095142 studies bdb nsc 24822964 cas 24822964 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb chembl21133022 studies bdb 2 3 furylmethyl 5 9 diethyl 2 39 hydroxy 6 7 benzomorphan cas 56649 76 4 mr22662 studies bdb chembl21133092 studies bdb nsc 44456785 cas 44456785 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb chembl21123732 studies bdb chembl32620922 studies bdb chembl21133762 studies bdb chembl30863052 studies bdb chembl33095092 studies bdb chembl3262090 us9480684 13a r ph bu126 us9259422 13a r ph bu1262 studies bdb 3 30 decane 1 10 diaminothiazolo bis cyclopropylmethyl morphinan chembl17749522 studies bdb chembl33092642 studies bdb 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epoxy 6 beta d glucopyranosyl2 studies bdb chembl33095072 studies bdb mcl 1452 studies bdb derivative of natrindole chembl706932 studies bdb bis 3 aminothiazolo n cyclopropylmethylmorphinan sebacamide chembl17749512 studies bdb nsc 24822459 nsc 24822965 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb nsc 24822460 cas 24822460 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb chembl6100122 studies bdb nsc 24824636 cas 24824636 17 cyclopropylmethyl 3 14 beta dihydroxy 4 5 alpha epo2 studies bdb chembl21128382 studies bdb chembl21132822 studies bdb 1s 9r 10r 5 amino 20 cyclopropylmethyl 6 thia 4 20 diazapentacyclo 8 7 3 0 1 9 02 studies bdb chembl32620912 studies bdb chembl33095182 studies bdb chembl32623622 studies bdb chembl3262089 us9480684 7a r ph bu127 us9259422 7a r ph bu1272 studies bdb chembl33095152 studies bdb chembl32623612 studies bdb chembl32620882 studies bdb 3 hydroxy 4 methoxy 17 methyl 18 1 phenyl e ethylidene 17 azapentacyclo 7 5 3 212 studies bdb 5 2 aminoethyl natrindole chembl728852 studies bdb 3 hydroxy 4 methoxy 17 methyl 18 1 phenyl e methylidene 17 azapentacyclo 7 5 3 22 studies bdb chembl11695822 studies bdb 7 7 spiro analogue ofbuprinorphine chembl310302 studies bdb metazocine2 studies bdb 1r 10r 17 cyclobutylmethyl 17 azatetracyclo 7 5 3 0 1 10 0 2 7 heptadeca 2 4 6 t2 studies bdb 7 amino 19 methyl 11 oxa 6 8 19 triazahexacyclo 10 9 1 01 10 02 18 04 9 016 22 d2 studies bdb 19 methyl 11 oxa 6 8 19 triazahexacyclo 10 9 1 01 10 02 18 04 9 016 22 docosa 4 2 studies bdb n trifluoroethyl aminothiazolo 5 4 b n cyclopropylmethyl morphinan chembl17660262 studies bdb 1 1s 2r 5r 8 2 3 4 dichlorophenyl acetyl 2 pyrrolidin 1 yl 6 8 diazabicyclo 3 2 2 studies bdb 7 7 spiro analogue ofbuprinorphine chembl4167652 studies bdb 1n 10 methoxy 4 methyl 14 oxo 13r 17s 12 oxa 4 azapentacyclo 9 6 1 01 13 05 17 02 studies bdb 1n 4 cyclopropylmethyl 10 hydroxy 14 oxo 13r 17s 12 oxa 4 azapentacyclo 9 6 1 012 studies bdb chembl23387452 studies bdb 1n 10 hydroxy 4 13 dimethyl 14 oxo 13r 17s 12 oxa 4 azapentacyclo 9 6 1 01 13 052 studies bdb chembl285250 3 2 methyl 2 aza bicyclo 3 3 1 non 5 yl phenol2 studies bdb 1n 4 cyclopropylmethyl 10 methoxy 14 oxo 13r 17s 12 oxa 4 azapentacyclo 9 6 1 012 studies bdb 20 cyclopropylmethyl 1r 12r 7 thia 5 20 diazapentacyclo 10 5 3 01 13 02 10 04 8 2 studies bdb chembl290855 5 3 hydroxy phenyl 2 methyl 2 aza bicyclo 3 3 1 nonan 9 ol2 studies bdb chembl36707 5 3 hydroxy phenyl 2 methyl 2 aza bicyclo 3 3 1 nonan 9 ol2 studies bdb 1n 4 cyclopropylmethyl 10 hydroxy 13 methyl 14 oxo 13r 17s 12 oxa 4 azapentacycl2 studies bdb chembl287726 5 3 hydroxy phenyl 2 methyl 2 aza bicyclo 3 3 1 nonan 9 ol 3 2 9 di2 studies bdb 1n 10 methoxy 4 13 dimethyl 14 oxo 13r 17s 12 oxa 4 azapentacyclo 9 6 1 01 13 052 studies bdb 1n 4 cyclopropylmethyl 10 methoxy 13 methyl 14 oxo 13r 17s 12 oxa 4 azapentacycl2 studies bdb chembl6070682 studies bdb 19 methyl 7 phenyl 11 oxa 6 8 19 triazahexacyclo 10 9 1 01 10 02 18 04 9 016 22 2 studies bdb chembl2605212 studies bdb 17 methyl 17 cyclopropylmethyl 3 hydroxy 6 6 7 7 tetradehydro 4 5 alpha 4 5 alph2 studies bdb 17 cyclopropylmethyl 17 acetyl 3 hydroxy 6 6 7 7 tetradehydro 4 5 alpha 4 5 alph2 studies bdb 1 1 6 6 dimethyl bicyclo 3 1 1 hept 2 ylmethyl piperidin 4 yl 1 3 dihydro indol 2 studies bdb chembl22058252 studies bdb chembl18344132 studies bdb 8 dio tolylmethyl 3 phenyl 8 azabicyclo 3 2 1 octan 3 ol chembl5131362 studies bdb naltrindole 8r 7 cyclopropylmethyl 5 6 7 8 14 14b hexahydro 4 8 methano 1 benzof5 studies bdb nsc 61677 cas 61677 etorphine hci4 studies bdb chembl37590923 studies bdb chembl23970163 studies bdb chembl23970173 studies bdb chembl23970183 studies bdb chembl23970223 studies bdb chembl23970193 studies bdb chembl23970213 studies bdb chembl23970153 studies bdb chembl23970203 studies bdb chembl46330202 studies bdb chembl46476962 studies bdb chembl46465072 studies bdb chembl46490422 studies bdb chembl46459522 studies bdb chembl46390052 studies bdb chembl46340072 studies bdb chembl46466782 studies bdb chembl46332232 studies bdb chembl37592382 studies bdb chembl46447312 studies bdb chembl46408262 studies bdb chembl46446912 studies bdb chembl46386672 studies bdb chembl46401392 studies bdb chembl46432562 studies bdb chembl46339072 studies bdb chembl46400172 studies bdb chembl46416702 studies bdb chembl46365982 studies bdb chembl46455332 studies bdb chembl46340792 studies bdb chembl46494852 studies bdb chembl46412712 studies bdb chembl46445432 studies bdb cas 115070 nsc 115070 beta c n a2 studies bdb chembl46333482 studies bdb chembl46387092 studies bdb chembl46478512 studies bdb chembl46340212 studies bdb chembl46357112 studies bdb chembl46498202 studies bdb chembl46401412 studies bdb chembl46473572 studies bdb chembl46466872 studies bdb chembl46341412 studies bdb chembl46348622 studies bdb chembl46332092 studies bdb chembl46455082 studies bdb chembl46361592 studies bdb cas 4424 nsc 4424 naloxonazine2 studies bdb chembl46486282 studies bdb chembl46449642 studies bdb chembl46473532 studies bdb chembl46489202 studies bdb chembl46496072 studies bdb chembl46471802 studies bdb chembl46363052 studies bdb chembl45620252 studies bdb chembl45299502 studies bdb chembl44644912 studies bdb chembl44627562 studies bdb chembl44720772 studies bdb chembl44593432 studies bdb chembl44578772 studies bdb chembl45428252 studies bdb chembl37583482 studies bdb chembl44397702 studies bdb chembl44521872 studies bdb chembl44457362 studies bdb chembl45211872 studies bdb chembl45741502 studies bdb chembl45618762 studies bdb chembl45434252 studies bdb chembl45166742 studies bdb chembl45343072 studies bdb chembl44357732 studies bdb chembl45510662 studies bdb chembl45754642 studies bdb chembl44537732 studies bdb chembl44423572 studies bdb chembl44682162 studies bdb chembl33608292 studies