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citrus vs perilla

Mechanistic comparison of citrus reticulata and perilla frutescens based on molecular target overlap from BindingDB and ChEMBL binding affinity data.

Compare in Research Workstation
6513
Shared Targets
67%
Jaccard Similarity
63%
IDF-Weighted Similarity
Jaccard measures raw target overlap. IDF-weighted downweights promiscuous hub targets (e.g. CYP enzymes) that bind many compounds non-specifically.

Evidence Comparison

citrus reticulata
Evidence Score
200
PubMed Studies
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perilla frutescens
Evidence Score
PubMed Studies
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Target Overlap

citrus and perilla share 6513 molecular targets based on binding affinity data from BindingDB (Kd/IC50 ≤ 10 µM) and ChEMBL. A Jaccard index of 0.674 means 67% of the combined target set is bound by both compounds. The IDF-weighted score of 0.635 accounts for non-specific binding to metabolic enzymes.

Note: High target overlap does not imply identical mechanism or therapeutic equivalence. Binding affinity, tissue distribution, bioavailability, and downstream signaling differ significantly between compounds even when they bind the same protein.

Frequently Asked Questions

What do citrus and perilla have in common?
citrus and perilla share 6513 molecular targets with a Jaccard similarity of 67%. Both bind overlapping sets of proteins based on BindingDB and ChEMBL binding affinity data.
Can citrus and perilla be combined?
citrus and perilla share 6513 molecular targets, suggesting potential pathway overlap. Combination use should be evaluated with a qualified healthcare professional. BiohacksAI does not provide medical advice.
Which has more research: citrus or perilla?
Both citrus and perilla have substantial PubMed research. View their individual profiles for full evidence scores.

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Similar to perilla

perilla vs lonicera6881 targetsperilla vs prunus6202 targetsperilla vs aloe6928 targetsperilla vs Zingiber6564 targetsperilla vs morus7012 targets
View full citrus profile →View full perilla profile →Browse all substances →