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gastrodia vs Vitis

Mechanistic comparison of gastrodia elata and Vitis based on molecular target overlap from BindingDB and ChEMBL binding affinity data.

Compare in Research Workstation
2884
Shared Targets
50%
Jaccard Similarity
48%
IDF-Weighted Similarity
Jaccard measures raw target overlap. IDF-weighted downweights promiscuous hub targets (e.g. CYP enzymes) that bind many compounds non-specifically.

Evidence Comparison

gastrodia elata
Evidence Score
200
PubMed Studies
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Vitis
Evidence Score
200
PubMed Studies
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Target Overlap

gastrodia and Vitis share 2884 molecular targets based on binding affinity data from BindingDB (Kd/IC50 ≤ 10 µM) and ChEMBL. A Jaccard index of 0.503 means 50% of the combined target set is bound by both compounds. The IDF-weighted score of 0.480 accounts for non-specific binding to metabolic enzymes.

Note: High target overlap does not imply identical mechanism or therapeutic equivalence. Binding affinity, tissue distribution, bioavailability, and downstream signaling differ significantly between compounds even when they bind the same protein.

Frequently Asked Questions

What do gastrodia and Vitis have in common?
gastrodia and Vitis share 2884 molecular targets with a Jaccard similarity of 50%. Both bind overlapping sets of proteins based on BindingDB and ChEMBL binding affinity data.
Can gastrodia and Vitis be combined?
gastrodia and Vitis share 2884 molecular targets, suggesting potential pathway overlap. Combination use should be evaluated with a qualified healthcare professional. BiohacksAI does not provide medical advice.
Which has more research: gastrodia or Vitis?
In the BiohacksAI corpus: gastrodia has 200 PubMed-indexed studies, Vitis has 200 studies.

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View full gastrodia profile →View full Vitis profile →Browse all substances →