Mechanistic comparison of Harmaline and Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine based on molecular target overlap from BindingDB and ChEMBL binding affinity data.
14
Shared Targets
22%
Jaccard Similarity
19%
IDF-Weighted Similarity
Jaccard measures raw target overlap. IDF-weighted downweights promiscuous hub targets (e.g. CYP enzymes) that bind many compounds non-specifically.
Harmaline and Harmine share 14 molecular targets based on binding affinity data from BindingDB (Kd/IC50 ≤ 10 µM) and ChEMBL. A Jaccard index of 0.219 means 22% of the combined target set is bound by both compounds. The IDF-weighted score of 0.192 accounts for non-specific binding to metabolic enzymes.
Note: High target overlap does not imply identical mechanism or therapeutic equivalence. Binding affinity, tissue distribution, bioavailability, and downstream signaling differ significantly between compounds even when they bind the same protein.
Frequently Asked Questions
What do Harmaline and Harmine have in common?
Harmaline and Harmine share 14 molecular targets with a Jaccard similarity of 22%. Both bind overlapping sets of proteins based on BindingDB and ChEMBL binding affinity data.
Can Harmaline and Harmine be combined?
Harmaline and Harmine share 14 molecular targets, suggesting potential pathway overlap. Combination use should be evaluated with a qualified healthcare professional. BiohacksAI does not provide medical advice.
Which has more research: Harmaline or Harmine?
In the BiohacksAI corpus: Harmaline has 300 PubMed-indexed studies, Harmine has 300 studies.