Compounds That Target CDK1

cyclin dependent kinase 1 · 175 compounds in BiohacksAI corpus

CDK1 (cyclin dependent kinase 1) is a protein kinase involved in intracellular signal transduction. Kinases phosphorylate downstream substrates to regulate cell growth, survival, and metabolism. The 175 compounds targeting CDK1 include both pharmaceutical inhibitors and natural compounds with evidence of kinase modulation, ranked by evidence strength from the BiohacksAI corpus.

View CDK1 target page →UniProt: P06493 ↗

Most Studied Compounds for CDK1

Sertraline

1.0k+

studies

Indirubin

300+

studies

Rotenone

300+

studies

Fenofibrate

297+

studies

Alsterpaullone

12+

studies

Kenpaullone

studies

Bdb 5s 6r 7r 9r 16r 16 Hydroxy 6 Methoxy 5 Methyl 7 Methylamino 6 7 8 9 15 16 Hexahy

studies

All 50 Compounds — Ranked by Evidence

Seliciclib

4.91

confidence

Alvocidib

4.52

confidence

Dinaciclib

3.87

confidence

Silmitasertib

3.78

confidence

Olomoucine

3.71

confidence

Abemaciclib

3.66

confidence

Sb 216763

3.53

confidence

6bio

3.50

confidence

Bms 387032

3.47

confidence

Linifanib

3.33

confidence

At 7519

3.33

confidence

Dabrafenib

3.30

confidence

Indirubin 3 Monoxime

3.22

confidence

Purvalanola

3.18

confidence

Jnj 7706621

3.09

confidence

Su 9516

2.83

confidence

Milciclib

2.77

confidence

Pf 00562271

2.77

confidence

Crenolanib

2.71

confidence

Azd 5438

2.71

confidence

Laduviglusib

2.71

confidence

Kenpaullone

studies

2.64

confidence

Zotiraciclib

2.56

confidence

Roniciclib

2.56

confidence

Isogranulatimide

2.56

confidence

Defactinib

2.48

confidence

Paullone

2.48

confidence

Alsterpaullone

12+

studies

2.40

confidence

Rebastinib

2.20

confidence

Ct 7001

2.20

confidence

Rg 547

2.08

confidence

Zemirciclib

2.08

confidence

Purvalanol B

2.08

confidence

Ebvaciclib

2.08

confidence

Paullone 2

2.08

confidence

Butyrolactone I

2.08

confidence

Gw280670x

1.95

confidence

S Roscovitine

1.95

confidence

Bohemine

1.95

confidence

Indirubin

300+

studies

1.79

confidence

Aigialomycin D

1.79

confidence

Voruciclib

1.79

confidence

Rs Roscovitine

1.79

confidence

Clofibratedrugage

1.39

confidence

Fenofibrate

297+

studies

1.39

confidence

Bdb 5s 6r 7r 9r 16r 16 Hydroxy 6 Methoxy 5 Methyl 7 Methylamino 6 7 8 9 15 16 Hexahy

studies

1.39

confidence

Sertraline

1.0k+

studies

1.10

confidence

Cinnarizinedrugage

1.10

confidence

Clotrimazoleheterocyclic

1.10

confidence

Rotenone

300+

studies

1.10

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for CDK1 (cyclin dependent kinase 1). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: CDK1 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.