BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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Compounds That Target CDK12

Cyclin-dependent kinase 12 · 10 compounds in BiohacksAI corpus

CDK12 (Cyclin-dependent kinase 12) is a protein kinase involved in intracellular signal transduction. Kinases phosphorylate downstream substrates to regulate cell growth, survival, and metabolism. The 10 compounds targeting CDK12 include both pharmaceutical inhibitors and natural compounds with evidence of kinase modulation, ranked by evidence strength from the BiohacksAI corpus.

All 10 Compounds — Ranked by Evidence
1
Alvocidib
4.52
confidence
2
Dinaciclib
3.87
confidence
3
Fasudil
3.66
confidence
4
Bms 387032
3.47
confidence
5
At 7519
3.33
confidence
6
Zotiraciclib
2.56
confidence
7
Defactinib
2.48
confidence
8
Rg 547
2.08
confidence
9
Amg 900
2.08
confidence
10
Istisociclib
2.08
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for CDK12 (Cyclin-dependent kinase 12). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: CDK12 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.