Compounds That Target CDK4

cyclin dependent kinase 4 · 160 compounds in BiohacksAI corpus

CDK4 (cyclin dependent kinase 4) is a protein kinase involved in intracellular signal transduction. Kinases phosphorylate downstream substrates to regulate cell growth, survival, and metabolism. The 160 compounds targeting CDK4 include both pharmaceutical inhibitors and natural compounds with evidence of kinase modulation, ranked by evidence strength from the BiohacksAI corpus.

View CDK4 target page →UniProt: P11802 ↗

Most Studied Compounds for CDK4

Allium Sativum

500+

studies

Bdb 5s 6r 7r 9r 16r 16 Hydroxy 6 Methoxy 5 Methyl 7 Methylamino 6 7 8 9 15 16 Hexahy

studies

All 50 Compounds — Ranked by Evidence

Seliciclib

4.91

confidence

Alvocidib

4.52

confidence

Palbociclib

4.22

confidence

Ceritinib

4.19

confidence

Bi 2536

4.01

confidence

Dinaciclib

3.87

confidence

Abemaciclib

3.66

confidence

Nintedanib

3.61

confidence

Bms 387032

3.47

confidence

Tae 684

3.43

confidence

Fedratinib

3.40

confidence

Gilteritinib

3.40

confidence

At 7519

3.33

confidence

Dabrafenib

3.30

confidence

Ribociclib

3.26

confidence

Purvalanola

3.18

confidence

Sulfuretin

3.14

confidence

Dovitinib

3.09

confidence

At 9283

3.09

confidence

Lestaurtinib

3.04

confidence

Ruboxistaurin

2.94

confidence

K 252a

2.83

confidence

Su 9516

2.83

confidence

Milciclib

2.77

confidence

Pha 665752

2.71

confidence

Azd 5438

2.71

confidence

Kw 2449

2.64

confidence

Fascaplysin Chloride

2.64

confidence

Ast 487

2.56

confidence

Roniciclib

2.56

confidence

Su 014813

2.20

confidence

Rebastinib

2.20

confidence

Encorafenib

2.20

confidence

Ct 7001

2.20

confidence

Cyc 116

2.08

confidence

Rg 547

2.08

confidence

Zemirciclib

2.08

confidence

Ebvaciclib

2.08

confidence

Gw779439x

2.08

confidence

Voruciclib

1.79

confidence

Ly 2090314

1.79

confidence

Bdb 5s 6r 7r 9r 16r 16 Hydroxy 6 Methoxy 5 Methyl 7 Methylamino 6 7 8 9 15 16 Hexahy

studies

1.39

confidence

Achyranthes Bidentata

1.00

confidence

Agastache Rugosa

1.00

confidence

Allium Sativum

500+

studies

1.00

confidence

Aloe Vera

1.00

confidence

Anemarrhena Asphodeloides

1.00

confidence

Arctium Lappa

1.00

confidence

Artemisia Annua

1.00

confidence

Artemisia Argyi

1.00

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for CDK4 (cyclin dependent kinase 4). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: CDK4 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.