Compounds That Target CDK5

cyclin dependent kinase 5 · 151 compounds in BiohacksAI corpus

CDK5 (cyclin dependent kinase 5) is a protein kinase involved in intracellular signal transduction. Kinases phosphorylate downstream substrates to regulate cell growth, survival, and metabolism. The 151 compounds targeting CDK5 include both pharmaceutical inhibitors and natural compounds with evidence of kinase modulation, ranked by evidence strength from the BiohacksAI corpus.

View CDK5 target page →UniProt: Q00535 ↗

Most Studied Compounds for CDK5

Indirubin

300+

studies

Harmine

300+

studies

Apigenin

300+

studies

Sorafenib

300+

studies

Egcg

300+

studies

Luteolin

150+

studies

Sp600125

117+

studies

Fisetin

78+

studies

Alsterpaullone

12+

studies

Ha1077

11+

studies

All 52 Compounds — Ranked by Evidence

Seliciclib

4.91

confidence

Alvocidib

4.52

confidence

Doramapimod

4.06

confidence

Dinaciclib

3.87

confidence

Silmitasertib

3.78

confidence

Olomoucine

3.71

confidence

Abemaciclib

3.66

confidence

6bio

3.50

confidence

Bms 387032

3.47

confidence

Tae 684

3.43

confidence

At 7519

3.33

confidence

Dabrafenib

3.30

confidence

Sulfuretin

3.14

confidence

Jnj 7706621

3.09

confidence

At 9283

3.09

confidence

Lestaurtinib

3.04

confidence

Hymenialdisine

3.00

confidence

K 252a

2.83

confidence

Su 9516

2.83

confidence

Milciclib

2.77

confidence

Pf 00562271

2.77

confidence

Crenolanib

2.71

confidence

Azd 5438

2.71

confidence

Ast 487

2.56

confidence

Zotiraciclib

2.56

confidence

Defactinib

2.48

confidence

Kenpaullone

studies

2.30

confidence

Alsterpaullone

12+

studies

2.20

confidence

Rebastinib

2.20

confidence

Ct 7001

2.20

confidence

Indirubin

300+

studies

2.08

confidence

Rg 547

2.08

confidence

Zemirciclib

2.08

confidence

S Roscovitine

1.95

confidence

Cyc 065

1.95

confidence

Pf 03814735

1.79

confidence

Aigialomycin D

1.79

confidence

Voruciclib

1.79

confidence

Rs Roscovitine

1.79

confidence

Harmine

300+

studies

1.39

confidence

Apigenin

300+

studies

1.10

confidence

Chrysinflavonoids

1.10

confidence

Fisetin

78+

studies

1.10

confidence

Luteolin

150+

studies

1.10

confidence

Ha1077

11+

studies

1.10

confidence

Sorafenib

300+

studies

1.10

confidence

Artemisia Argyi

1.00

confidence

Agastache Rugosa

1.00

confidence

Aloe Vera

1.00

confidence

Achyranthes Bidentata

1.00

confidence

Sp600125

117+

studies

0.69

confidence

Egcg

300+

studies

0.69

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for CDK5 (cyclin dependent kinase 5). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: CDK5 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.