Compounds That Target CDKL5

Cyclin-dependent kinase-like 5 · 35 compounds in BiohacksAI corpus

CDKL5 (Cyclin-dependent kinase-like 5) is a protein kinase involved in intracellular signal transduction. Kinases phosphorylate downstream substrates to regulate cell growth, survival, and metabolism. The 35 compounds targeting CDKL5 include both pharmaceutical inhibitors and natural compounds with evidence of kinase modulation, ranked by evidence strength from the BiohacksAI corpus.

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Most Studied Compounds for CDKL5

Raphanus Sativus

500+

studies

Zingiber Officinale

498+

studies

Areca Catechu

199+

studies

All 35 Compounds — Ranked by Evidence

Alvocidib

4.52

confidence

Foretinib

4.34

confidence

Tozasertib

4.33

confidence

Bms 387032

3.47

confidence

Fedratinib

3.40

confidence

At 7519

3.33

confidence

Lestaurtinib

3.04

confidence

Pf 03758309

3.00

confidence

Ruboxistaurin

2.94

confidence

Ast 487

2.56

confidence

Defactinib

2.48

confidence

Capmatinib

2.20

confidence

Rg 547

2.08

confidence

Bupleurum Chinense

1.00

confidence

Allium Tuberosum

0.50

confidence

Arctium Lappa

0.50

confidence

Areca Catechu

199+

studies

0.50

confidence

Cnidium Monnieri

0.50

confidence

Cuscuta Chinensis

0.50

confidence

Ephedra Sinica

0.50

confidence

Eucommia Ulmoides

0.50

confidence

Lithospermum Erythrorhizon

0.50

confidence

Lonicera Japonica

0.50

confidence

Morinda Officinalis

0.50

confidence

Morus Alba

0.50

confidence

Nelumbo Nucifera

0.50

confidence

Peucedanum Praeruptorum

0.50

confidence

Prunella Vulgaris

0.50

confidence

Pulsatilla Chinensis

0.50

confidence

Raphanus Sativus

500+

studies

0.50

confidence

Saposhnikovia Divaricata

0.50

confidence

Trichosanthes Kirilowii

0.50

confidence

Verbena Officinalis

0.50

confidence

Zingiber Officinale

498+

studies

0.50

confidence

Ziziphus Jujuba

0.50

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for CDKL5 (Cyclin-dependent kinase-like 5). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: CDKL5 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.