Compounds That Target CYP2D6

cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) · 360 compounds in BiohacksAI corpus

CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) is a cytochrome P450 enzyme involved in the metabolism of drugs, hormones, and dietary compounds. CYP enzymes are critical determinants of pharmacokinetics and drug-herb interactions. The 360 compounds listed here have documented interactions with CYP2D6 based on BindingDB inhibition and binding assay data, making this resource valuable for assessing compound safety and interaction profiles.

View CYP2D6 target page →UniProt: ANW61984 ↗

Most Studied Compounds for CYP2D6

Methoxypsoralen

300+

studies

Kaempferol

300+

studies

Yohimbine

299+

studies

Chlorhexidine

299+

studies

Cyproheptadine

299+

studies

Maprotiline

299+

studies

Quinidine

298+

studies

Oxymetazoline

298+

studies

Danazol

298+

studies

Dextromethorphan

296+

studies

All 50 Compounds — Ranked by Evidence

Tacrine

6.08

confidence

Sb 203580

4.92

confidence

Risperidone

4.89

confidence

Berberine Chloride

4.56

confidence

Propafenone

4.53

confidence

Thioridazine

4.52

confidence

Terbinafine

4.52

confidence

Paroxetine

4.39

confidence

Quinidine

298+

studies

4.33

confidence

Clomipramine

4.28

confidence

Mibefradil

4.26

confidence

Promazine

4.19

confidence

Pyrilamine

4.17

confidence

Gentian Violet

4.03

confidence

Lansoprazole

4.01

confidence

Loperamide

3.93

confidence

Ticlopidine

3.85

confidence

Perhexiline

3.37

confidence

Prochlorperazine

3.33

confidence

Triamterene

3.30

confidence

Idebenone

3.22

confidence

Orphenadrine

2.94

confidence

Benzylimidazole

2.89

confidence

Carmofur

2.89

confidence

Bambuterol

2.77

confidence

Bromhexine

2.64

confidence

Clemastine

2.56

confidence

Methapyrilene

2.56

confidence

Yohimbine

299+

studies

2.48

confidence

Sulconazole

2.48

confidence

Oxiconazole

2.48

confidence

Ambroxol

2.48

confidence

Dextromethorphan

296+

studies

2.40

confidence

Trihexyphenidyl

2.40

confidence

Chlorhexidine

299+

studies

2.30

confidence

Cyproheptadine

299+

studies

2.30

confidence

Maprotiline

299+

studies

2.30

confidence

Methoxypsoralen

300+

studies

2.30

confidence

Oxymetazoline

298+

studies

2.30

confidence

Thimerosal

2.30

confidence

Amitifadine

2.30

confidence

Nortriptyline

295+

studies

2.20

confidence

Butenafine

2.20

confidence

Kaempferol

300+

studies

2.08

confidence

Amoxapine

259+

studies

2.08

confidence

Astemizole

280+

studies

2.08

confidence

Celecoxib

295+

studies

2.08

confidence

Danazol

298+

studies

2.08

confidence

Fluspirilene

74+

studies

2.08

confidence

Loratadine

296+

studies

2.08

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: CYP2D6 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.