Compounds That Target EGFR

epidermal growth factor receptor · 258 compounds in BiohacksAI corpus

EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase and major driver of cell proliferation. It is one of the most targeted proteins in oncology and has been studied in the context of natural compound inhibition. The 258 compounds below include approved targeted therapies as well as polyphenols and flavonoids with evidence of EGFR interaction from the BiohacksAI BindingDB corpus.

View EGFR target page →UniProt: P00533 ↗

All 50 Compounds — Ranked by Evidence

Tamoxifen

5.88

confidence

Gefitinib

5.67

confidence

Erlotinib

5.55

confidence

Imatinib

5.47

confidence

Osimertinib

5.03

confidence

Sb 203580

4.92

confidence

Ibrutinib

4.86

confidence

Lapatinib

4.84

confidence

Docetaxel

4.63

confidence

Terfenadine

4.55

confidence

Alvocidib

4.52

confidence

Thioridazine

4.52

confidence

Nelfinavir

4.51

confidence

Cabozantinib

4.39

confidence

Foretinib

4.34

confidence

Vandetanib

4.30

confidence

Caffeic Acid Phenethyl Ester

4.25

confidence

Ceritinib

4.19

confidence

Shikonin

4.11

confidence

Bosutinib

4.08

confidence

Doramapimod

4.06

confidence

Gentian Violet

4.03

confidence

Bi 2536

4.01

confidence

Fluphenazine

3.91

confidence

Zafirlukast

3.89

confidence

Midostaurin

3.85

confidence

Brigatinib

3.81

confidence

Ciglitazone

3.81

confidence

Catechol

3.76

confidence

Vatalanib

3.69

confidence

Neratinib

3.66

confidence

Sb 202190

3.64

confidence

Canertinib

3.53

confidence

Pelitinib

3.50

confidence

Candesartan

3.47

confidence

Tae 684

3.43

confidence

Fedratinib

3.40

confidence

Gilteritinib

3.40

confidence

Dobutamine

3.37

confidence

Perhexiline

3.37

confidence

Linifanib

3.33

confidence

Mln 8054

3.33

confidence

Saracatinib

3.33

confidence

Tandutinib

3.22

confidence

Acalabrutinib

3.22

confidence

Rociletinib

3.18

confidence

Gw305074x

3.14

confidence

Pyrogallol

3.14

confidence

Dacomitinib Anhydrous

3.14

confidence

Dovitinib

3.09

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for EGFR (epidermal growth factor receptor). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: EGFR target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.