BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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Compounds That Target HDAC8

histone deacetylase 8 · 135 compounds in BiohacksAI corpus

HDAC8 (histone deacetylase 8) is a biological target with 135 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into HDAC8 modulation for therapeutic and biohacking applications.

Most Studied Compounds for HDAC8
500+
studies
300+
studies
300+
studies
300+
studies
300+
studies
300+
studies
300+
studies
299+
studies
298+
studies
296+
studies
All 58 Compounds — Ranked by Evidence
1
Trichostatin
5.45
confidence
299+
studies
5.19
confidence
3
Entinostat
4.88
confidence
300+
studies
4.72
confidence
5
Tubastatin A
4.65
confidence
6
Panobinostat
4.26
confidence
7
Ricolinostat
4.08
confidence
8
Romidepsin
3.95
confidence
9
Belinostat
3.91
confidence
10
Oxyquinoline
3.85
confidence
11
Apicidin
3.58
confidence
12
Tubacin
3.56
confidence
13
Mocetinostat
3.30
confidence
14
Benzohydroxamate
3.26
confidence
15
Largazole
3.26
confidence
16
Nexturastat A
3.14
confidence
17
Dacinostat
3.04
confidence
18
Tucidinostat
3.04
confidence
19
Citarinostat
2.94
confidence
20
Quisinostat
2.94
confidence
21
Sodium Butyrate
2.94
confidence
53+
studies
2.89
confidence
23
Fimepinostat
2.89
confidence
24
Hinokitiol
2.89
confidence
25
Phenylbutanoic Acid
2.89
confidence
26
Bendamustine
2.71
confidence
27
Pracinostat
2.48
confidence
28
Suberohydroxamic Acid
2.48
confidence
29
Cudc 101
2.40
confidence
30
Phenylacetohydroxamic Acid
2.40
confidence
31
Givinostat
2.30
confidence
32
Oxamflatin
2.20
confidence
33
Phenylbutyrylhydroxamic Acid
2.08
confidence
34
Aureusidin
2.08
confidence
35
Abexinostat
2.08
confidence
36
Azumamide E
1.79
confidence
37
Ar 42
1.79
confidence
38
8 Mercapto Octanoic Acid Phenylamide
1.79
confidence
296+
studies
1.61
confidence
40
Pictilisibdrugage
1.61
confidence
300+
studies
1.39
confidence
298+
studies
1.10
confidence
300+
studies
1.00
confidence
44
Citrus Reticulata
1.00
confidence
500+
studies
1.00
confidence
46
Epimedium Brevicornum
1.00
confidence
47
Glycyrrhiza Uralensis
1.00
confidence
48
Lonicera Japonica
1.00
confidence
49
Morus Alba
1.00
confidence
1.00
confidence
300+
studies
0.69
confidence
2+
studies
0.69
confidence
2+
studies
0.69
confidence
2+
studies
0.69
confidence
295+
studies
0.69
confidence
300+
studies
0.69
confidence
300+
studies
0.69
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for HDAC8 (histone deacetylase 8). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: HDAC8 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.