Compounds That Target HTR1A

5-hydroxytryptamine receptor 1A · 278 compounds in BiohacksAI corpus

HTR1A (5-hydroxytryptamine receptor 1A) is a receptor that mediates ligand-dependent signaling relevant to physiology, behavior, and metabolism. The 278 compounds with documented HTR1A interactions span synthetic agonists, antagonists, and natural ligands identified through BindingDB binding assays and PubMed literature in the BiohacksAI corpus.

View HTR1A target page →UniProt: P08908 ↗

Most Studied Compounds for HTR1A

Buspirone

299+

studies

Aripiprazole

298+

studies

All 50 Compounds — Ranked by Evidence

Clozapine

5.81

confidence

Serotonin

5.47

confidence

8 Oh Dpat

4.98

confidence

Risperidone

4.89

confidence

Ketanserin

4.85

confidence

Olanzapine

4.44

confidence

Paroxetine

4.39

confidence

Spiperone

4.23

confidence

Ziprasidone

3.99

confidence

Fluphenazine

3.91

confidence

Buspirone

299+

studies

3.83

confidence

Nefazodone

3.71

confidence

Metitepine

3.71

confidence

Ritanserin

3.61

confidence

Lysergide

3.61

confidence

Sertindole

3.58

confidence

Tropisetron

3.58

confidence

Way 100635

3.53

confidence

Shogaol

3.47

confidence

Mirtazapine

3.43

confidence

Chlorophenylpiperazine

3.37

confidence

Nan 190

3.37

confidence

Mebufotenin

3.33

confidence

Rauwolscine

3.30

confidence

Ropinirole

3.26

confidence

L 745870

3.22

confidence

Bmy 7378

3.22

confidence

5 Methoxytryptamine

3.18

confidence

Bp 897

3.18

confidence

Mesulergine

3.18

confidence

Zolmitriptan

3.18

confidence

Intepirdine

3.14

confidence

Ipsapirone

3.04

confidence

Rizatriptan

3.00

confidence

Pptn

2.89

confidence

5 Oh Dpat

2.89

confidence

Nn Dimethyltryptamine

2.89

confidence

Cariprazine

2.83

confidence

Psilocin

2.77

confidence

Vilazodone

2.77

confidence

Ebastine

2.64

confidence

Propranolol Hydrochloride

2.64

confidence

Fauc 113

2.64

confidence

Niguldipine

2.56

confidence

Idalopirdine

2.56

confidence

Bufotenine

2.56

confidence

Bay 293

2.48

confidence

Cirazoline

2.48

confidence

Aripiprazole

298+

studies

2.40

confidence

Penfluridol

2.40

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for HTR1A (5-hydroxytryptamine receptor 1A). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: HTR1A target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.