BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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BiohacksAI/Targets/HTR4/Compounds

Compounds That Target HTR4

5-hydroxytryptamine receptor 4 · 123 compounds in BiohacksAI corpus

HTR4 (5-hydroxytryptamine receptor 4) is a receptor that mediates ligand-dependent signaling relevant to physiology, behavior, and metabolism. The 123 compounds with documented HTR4 interactions span synthetic agonists, antagonists, and natural ligands identified through BindingDB binding assays and PubMed literature in the BiohacksAI corpus.

View HTR4 target page →UniProt: Q13639 ↗
Most Studied Compounds for HTR4
1
Portulaca Oleracea
500+
studies
2
Raphanus Sativus
500+
studies
3
Curcuma Longa
500+
studies
4
Zingiber Officinale
498+
studies
5
Mescaline
300+
studies
6
Panax Ginseng
300+
studies
7
Pergolide
299+
studies
8
Ginkgo Biloba
299+
studies
9
Cyproheptadine
299+
studies
10
Amitriptyline
299+
studies
All 50 Compounds — Ranked by Evidence
1
Serotonin
5.47
confidence
2
Tropisetron
3.58
confidence
3
Rel Cisapride
3.40
confidence
4
5 Methoxytryptamine
3.18
confidence
5
Tegaserod
2.89
confidence
6
Metoclopramide
297+
studies
2.20
confidence
7
Prucalopride
2.20
confidence
8
Mescaline
300+
studies
1.10
confidence
9
Pergolide
299+
studies
1.10
confidence
10
Panax Notoginseng
1.00
confidence
11
Portulaca Oleracea
500+
studies
1.00
confidence
12
Raphanus Sativus
500+
studies
1.00
confidence
13
Rehmannia Glutinosa
1.00
confidence
14
Schisandra Chinensis
1.00
confidence
15
Trichosanthes Kirilowii
1.00
confidence
16
Zingiber Officinale
498+
studies
1.00
confidence
17
Ziziphus Jujuba
1.00
confidence
18
Allium Tuberosum
1.00
confidence
19
Apis Mellifera
1.00
confidence
20
Artemisia Capillaris
1.00
confidence
21
Aster Tataricus
1.00
confidence
22
Atractylodes Macrocephala
1.00
confidence
23
Bombyx Mori
1.00
confidence
24
Bufo Bufo
1.00
confidence
25
Citrus Reticulata
1.00
confidence
26
Curcuma Longa
500+
studies
1.00
confidence
27
Ephedra Sinica
1.00
confidence
28
Eriobotrya Japonica
1.00
confidence
29
Forsythia Suspensa
1.00
confidence
30
Fritillaria Cirrhosa
1.00
confidence
31
Gastrodia Elata
1.00
confidence
32
Ginkgo Biloba
299+
studies
1.00
confidence
33
Glycyrrhiza Uralensis
1.00
confidence
34
Litchi Chinensis
1.00
confidence
35
Lithospermum Erythrorhizon
1.00
confidence
36
Lonicera Japonica
1.00
confidence
37
Morus Alba
1.00
confidence
38
Nelumbo Nucifera
1.00
confidence
39
Paeonia Lactiflora
1.00
confidence
40
Panax Ginseng
300+
studies
1.00
confidence
41
Perilla Frutescens
1.00
confidence
42
Pinellia Ternata
1.00
confidence
43
Polygala Tenuifolia
1.00
confidence
44
Nortriptyline
295+
studies
0.69
confidence
45
Cyproheptadine
299+
studies
0.69
confidence
46
Metergoline
144+
studies
0.69
confidence
47
Amitriptyline
299+
studies
0.69
confidence
48
Ondansetron
299+
studies
0.69
confidence
49
Mianserin
299+
studies
0.69
confidence
50
Achyranthes Bidentata
0.50
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for HTR4 (5-hydroxytryptamine receptor 4). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: HTR4 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.