Compounds That Target HTR5A

5-hydroxytryptamine receptor 5A · 161 compounds in BiohacksAI corpus

HTR5A (5-hydroxytryptamine receptor 5A) is a receptor that mediates ligand-dependent signaling relevant to physiology, behavior, and metabolism. The 161 compounds with documented HTR5A interactions span synthetic agonists, antagonists, and natural ligands identified through BindingDB binding assays and PubMed literature in the BiohacksAI corpus.

View HTR5A target page →UniProt: P35364 ↗

Most Studied Compounds for HTR5A

Curcuma Longa

500+

studies

Methysergide

300+

studies

Mescaline

300+

studies

Digoxigenin

300+

studies

Sorafenib

300+

studies

Digitoxigenin

300+

studies

Ergotamine

299+

studies

Yohimbine

299+

studies

Pergolide

299+

studies

Lisuride

299+

studies

All 60 Compounds — Ranked by Evidence

Clozapine

5.81

confidence

Serotonin

5.47

confidence

8 Oh Dpat

4.98

confidence

Risperidone

4.89

confidence

Ketanserin

4.85

confidence

Spiperone

4.23

confidence

Metitepine

3.71

confidence

Lysergide

3.61

confidence

Ritanserin

3.61

confidence

Purvalanola

3.18

confidence

Psilocin

2.77

confidence

Tryptoline

2.71

confidence

Prazosin Hydrochloride

2.64

confidence

Niguldipine

2.56

confidence

Bay 293

2.48

confidence

Ergotamine

299+

studies

2.48

confidence

Zacopride

2.40

confidence

Latrepirdine

2.40

confidence

Penfluridol

2.40

confidence

Sumatriptan

298+

studies

2.08

confidence

Fananserin

2.08

confidence

Nantenine

2.08

confidence

Spiroxatrine

1.95

confidence

Brexpiprazole

1.79

confidence

Methysergide

300+

studies

1.61

confidence

Yohimbine

299+

studies

1.39

confidence

Lysergic Acid Diethylamide

298+

studies

1.39

confidence

Mescaline

300+

studies

1.10

confidence

Metergoline

144+

studies

1.10

confidence

Pergolide

299+

studies

1.10

confidence

Pindololorganic

1.10

confidence

Bufotenin

93+

studies

1.10

confidence

Digoxigenin

300+

studies

1.10

confidence

Dihydroergotamine Methanesulfonate

studies

1.10

confidence

Forsythia Suspensa

1.00

confidence

Agastache Rugosa

1.00

confidence

Allium Tuberosum

1.00

confidence

Aloe Vera

1.00

confidence

Apis Mellifera

1.00

confidence

Artemisia Annua

1.00

confidence

Artemisia Capillaris

1.00

confidence

Aster Tataricus

1.00

confidence

Atractylodes Macrocephala

1.00

confidence

Bombyx Mori

1.00

confidence

Bufo Bufo

1.00

confidence

Bupleurum Chinense

1.00

confidence

Citrus Reticulata

1.00

confidence

Curcuma Longa

500+

studies

1.00

confidence

Ephedra Sinica

1.00

confidence

Eriobotrya Japonica

1.00

confidence

Vortioxetine

294+

studies

0.69

confidence

Sorafenib

300+

studies

0.69

confidence

Nortriptyline

295+

studies

0.69

confidence

Loxapine

225+

studies

0.69

confidence

Lisuride

299+

studies

0.69

confidence

Lanatosides

115+

studies

0.69

confidence

Hydroxyzine

298+

studies

0.69

confidence

Dihydroergotoxine

208+

studies

0.69

confidence

Digoxin

299+

studies

0.69

confidence

Digitoxigenin

300+

studies

0.69

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for HTR5A (5-hydroxytryptamine receptor 5A). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: HTR5A target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.