Compounds That Target MTOR

mechanistic target of rapamycin kinase · 189 compounds in BiohacksAI corpus

mTOR (mechanistic target of rapamycin) is a serine/threonine kinase and master regulator of cell growth, protein synthesis, and autophagy. mTOR inhibition — achievable through rapamycin, caloric restriction mimetics, and certain polyphenols — is one of the most reproducible interventions for lifespan extension across model organisms. The 189 compounds listed here represent the full spectrum of mTOR modulators documented in the BiohacksAI corpus.

View MTOR target page →UniProt: P42345 ↗

Most Studied Compounds for MTOR

Rapamycin

300+

studies

Rotenone

300+

studies

Thapsigargin

300+

studies

Wortmannin

300+

studies

Idazoxan

300+

studies

Idarubicin

299+

studies

Everolimus

297+

studies

Alpelisib

227+

studies

Calcimycin

216+

studies

Tanespimycin

33+

studies

All 50 Compounds — Ranked by Evidence

Epigalocatechin Gallate

5.40

confidence

Ly 294002

4.84

confidence

Sirolimus

4.82

confidence

Tacrolimus Anhydrous

4.45

confidence

Dactolisib

4.25

confidence

Pi 103

4.17

confidence

Rapamycin

300+

studies

3.87

confidence

Zstk 474

3.56

confidence

Buparlisib

3.40

confidence

Torin 1

10+

studies

3.26

confidence

Omipalisib

3.14

confidence

Pictilisibdrugage

2.94

confidence

Ku 55933

2.94

confidence

Fimepinostat

2.89

confidence

Azd 8055

2.89

confidence

Everolimus

297+

studies

2.83

confidence

Ly294002

11+

studies

2.83

confidence

Apitolisib

2.71

confidence

Pf 04691502

2.64

confidence

Sapanisertib

2.64

confidence

Gedatolisib

2.56

confidence

Ku0063794

studies

2.48

confidence

Vistusertib

2.48

confidence

2 Phenylimidazole

2.48

confidence

Torin1

2.40

confidence

Copanlisib

2.40

confidence

Berzosertib

2.30

confidence

Azd 6482

2.30

confidence

Bimiralisib

2.30

confidence

Azd 7648

2.30

confidence

Vs 5584

2.30

confidence

Bgt 226 Free Base

2.20

confidence

Gpi 1046

2.20

confidence

Ku 0063794

2.20

confidence

Tg100 115

2.08

confidence

Osi 027

2.08

confidence

Voxtalisib

2.08

confidence

Ceralasertib

2.08

confidence

Rotenone

300+

studies

1.95

confidence

Gsk 1059615

1.95

confidence

Rg 7603

1.95

confidence

Thapsigargin

300+

studies

1.39

confidence

Wortmannin

300+

studies

1.39

confidence

Alpelisib

227+

studies

1.10

confidence

Amn082

29+

studies

1.10

confidence

Calcimycin

216+

studies

1.10

confidence

Idarubicin

299+

studies

1.10

confidence

Idazoxan

300+

studies

1.10

confidence

Niclosamideorganic

1.10

confidence

Tanespimycin

33+

studies

1.10

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for MTOR (mechanistic target of rapamycin kinase). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: MTOR target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.