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BiohacksAI/Targets/OPRK/Compounds

Compounds That Target OPRK

Kappa-type opioid receptor · 270 compounds in BiohacksAI corpus

OPRK (Kappa-type opioid receptor) is a biological target with 270 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into OPRK modulation for therapeutic and biohacking applications.

View OPRK target page →
Most Studied Compounds for OPRK
1
Bdb Chebi 3216 Buprenorphine
7+
studies
2
Bdb Naltrindole 8r 7 Cyclopropylmethyl 5 6 7 8 14 14b Hexahydro 4 8 Methano 1 Benzof
5+
studies
3
Bdb Naloxone Nsc 10064 Cas 465 65 6 Naloxone
4+
studies
4
Bdb Nsc 223652 Cas 29485 83 4 Codeine Codeine Sulfate
4+
studies
5
Bdb Nsc 61677 Cas 61677 Etorphine Hci
4+
studies
6
Bdb Cas 105618 26 6 Nsc 3034416 Nor Bni
3+
studies
7
Bdb Buprenorphine Buprenorphine2 3 Cyclopropylmethyl 11 Hydroxy 15 Methoxy 13 Oxa 3
3+
studies
8
Bdb Cas 115077 Nsc 115077 Win 44 441
3+
studies
9
Bdb Cas 27943 Naltrexone Hcl Nsc 27943 Naltrexone
3+
studies
10
Bdb Chembl2113666
3+
studies
All 50 Compounds — Ranked by Evidence
1
Bdb Chebi 3216 Buprenorphine
7+
studies
1.95
confidence
2
Bdb Naltrindole 8r 7 Cyclopropylmethyl 5 6 7 8 14 14b Hexahydro 4 8 Methano 1 Benzof
5+
studies
1.61
confidence
3
Bdb Naloxone Nsc 10064 Cas 465 65 6 Naloxone
4+
studies
1.39
confidence
4
Bdb Nsc 223652 Cas 29485 83 4 Codeine Codeine Sulfate
4+
studies
1.39
confidence
5
Bdb Nsc 61677 Cas 61677 Etorphine Hci
4+
studies
1.39
confidence
6
Bdb Cas 105618 26 6 Nsc 3034416 Nor Bni
3+
studies
1.10
confidence
7
Bdb Buprenorphine Buprenorphine2 3 Cyclopropylmethyl 11 Hydroxy 15 Methoxy 13 Oxa 3
3+
studies
1.10
confidence
8
Bdb Cas 115077 Nsc 115077 Win 44 441
3+
studies
1.10
confidence
9
Bdb Cas 27943 Naltrexone Hcl Nsc 27943 Naltrexone
3+
studies
1.10
confidence
10
Bdb Chembl2113666
3+
studies
1.10
confidence
11
Bdb Chembl2397015
3+
studies
1.10
confidence
12
Bdb Chembl2397016
3+
studies
1.10
confidence
13
Bdb Chembl2397017
3+
studies
1.10
confidence
14
Bdb Chembl2397018
3+
studies
1.10
confidence
15
Bdb Chembl2397019
3+
studies
1.10
confidence
16
Bdb Chembl2397020
3+
studies
1.10
confidence
17
Bdb Chembl2397021
3+
studies
1.10
confidence
18
Bdb Chembl2397022
3+
studies
1.10
confidence
19
Bdb Chembl3759092
3+
studies
1.10
confidence
20
Bdb Chembl378753 Nalbzoh
3+
studies
1.10
confidence
21
Bdb Mcl 183 Chembl390866
3+
studies
1.10
confidence
22
Bdb 1n 10 Hydroxy 4 Methyl 14 Oxo 13r 17s 12 Oxa 4 Azapentacyclo 9 6 1 01 13 05 17 0
3+
studies
1.10
confidence
23
Bdb Chembl516641 Hyperforin
2+
studies
0.69
confidence
24
Bdb Chembl2205836
2+
studies
0.69
confidence
25
Bdb Chembl2205811
2+
studies
0.69
confidence
26
Bdb Chembl2205812
2+
studies
0.69
confidence
27
Bdb Chembl2205813
2+
studies
0.69
confidence
28
Bdb Chembl2205823
2+
studies
0.69
confidence
29
Bdb Chembl2205825
2+
studies
0.69
confidence
30
Bdb Chembl1189234 Chembl538300 11 Benzyl 11 Azahexacyclo 5 4 1 02 6 03 10 04 8 09 12
2+
studies
0.69
confidence
31
Bdb Chembl3360829
2+
studies
0.69
confidence
32
Bdb Chembl3262088
2+
studies
0.69
confidence
33
Bdb Chembl3262089 Us9480684 7a R Ph Bu127 Us9259422 7a R Ph Bu127
2+
studies
0.69
confidence
34
Bdb Chembl3262091
2+
studies
0.69
confidence
35
Bdb Chembl3262361
2+
studies
0.69
confidence
36
Bdb Chembl3262362
2+
studies
0.69
confidence
37
Bdb Chembl3309515
2+
studies
0.69
confidence
38
Bdb Chembl3309518
2+
studies
0.69
confidence
39
Bdb Chembl4062717 Us10377763 Example 34
2+
studies
0.69
confidence
40
Bdb Chembl4066535
2+
studies
0.69
confidence
41
Bdb Chembl4071362
2+
studies
0.69
confidence
42
Bdb Chembl4080914
2+
studies
0.69
confidence
43
Bdb Chembl4846243
2+
studies
0.69
confidence
44
Bdb Chembl4871880
2+
studies
0.69
confidence
45
Bdb 1 1 6 6 Dimethyl Bicyclo 3 1 1 Hept 2 Ylmethyl Piperidin 4 Yl 1 3 Dihydro Indol
2+
studies
0.69
confidence
46
Bdb 1 Adamantan 1 Yl 3 2 2 Amino 3 4 Hydroxy 2 6 Dimethyl Phenyl Propionyl 1 2 3 4 T
2+
studies
0.69
confidence
47
Bdb 17 Cyclopropylmethyl 3 14 Beta Dihydroxy 4 5 Alpha Epoxy 6 Beta D Glucopyranosyl
2+
studies
0.69
confidence
48
Bdb 1s 9r 10r 5 Amino 20 Cyclobutylmethyl 6 Thia 4 20 Diazapentacyclo 8 7 3 0 1 9 0
2+
studies
0.69
confidence
49
Bdb 1s 9r 10r 5 Amino 20 Cyclopropylmethyl 6 Thia 4 20 Diazapentacyclo 8 7 3 0 1 9 0
2+
studies
0.69
confidence
50
Bdb 2 3 Furylmethyl 5 9 Diethyl 2 39 Hydroxy 6 7 Benzomorphan Cas 56649 76 4 Mr2266
2+
studies
0.69
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for OPRK (Kappa-type opioid receptor). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: OPRK target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.