Compounds That Target PRKAA1

protein kinase AMP-activated catalytic subunit alpha 1 · 45 compounds in BiohacksAI corpus

PRKAA1 encodes the catalytic alpha-1 subunit of AMP-activated protein kinase (AMPK) — the cell's primary energy sensor activated by low ATP states, exercise, and caloric restriction. AMPK activation promotes mitochondrial biogenesis, glucose uptake, fatty acid oxidation, and autophagy while suppressing mTORC1. The 45 compounds targeting PRKAA1 include metformin, berberine, and numerous natural polyphenols studied for metabolic and longevity benefits.