Compounds That Target PRKAA1

protein kinase AMP-activated catalytic subunit alpha 1 · 151 compounds in BiohacksAI corpus

PRKAA1 encodes the catalytic alpha-1 subunit of AMP-activated protein kinase (AMPK) — the cell's primary energy sensor activated by low ATP states, exercise, and caloric restriction. AMPK activation promotes mitochondrial biogenesis, glucose uptake, fatty acid oxidation, and autophagy while suppressing mTORC1. The 151 compounds targeting PRKAA1 include metformin, berberine, and numerous natural polyphenols studied for metabolic and longevity benefits.

View PRKAA1 target page →UniProt: Q13131 ↗

Most Studied Compounds for PRKAA1

Metformin

1.0k+

studies

Adenosine Monophosphate

300+

studies

Ursolic Acid

300+

studies

Oleanolic Acid

300+

studies

Rotenone

300+

studies

Antimycin A

300+

studies

Berberine

300+

studies

Proguanil

299+

studies

Crizotinib

298+

studies

Fccp

76+

studies

All 53 Compounds — Ranked by Evidence

Alvocidib

4.52

confidence

Foretinib

4.34

confidence

Tozasertib

4.33

confidence

Vandetanib

4.30

confidence

Bosutinib

4.08

confidence

Midostaurin

3.85

confidence

Silmitasertib

3.78

confidence

Nintedanib

3.61

confidence

Bms 387032

3.47

confidence

Tae 684

3.43

confidence

Fedratinib

3.40

confidence

Upadacitinib

3.09

confidence

Dovitinib

3.09

confidence

Jnj 7706621

3.09

confidence

At 9283

3.09

confidence

Lestaurtinib

3.04

confidence

Pf 03758309

3.00

confidence

Danusertib

2.94

confidence

R 406

2.83

confidence

K 252a

2.83

confidence

Hesperadin

2.77

confidence

Capivasertib

2.77

confidence

Crenolanib

2.71

confidence

Pha 665752

2.71

confidence

Kw 2449

2.64

confidence

Ast 487

2.56

confidence

Raf 265

2.48

confidence

Ripasudil

2.40

confidence

Bms 754807

2.30

confidence

Azd 7762

2.30

confidence

Su 014813

2.20

confidence

Cyc 116

2.08

confidence

Adenosine Monophosphate

300+

studies

2.08

confidence

Proguanil

299+

studies

1.95

confidence

Pf 03814735

1.79

confidence

Ucn 01

1.79

confidence

Fccp

76+

studies

1.61

confidence

Niclosamideorganic

1.39

confidence

Ursolic Acid

300+

studies

1.10

confidence

Oleanolic Acid

300+

studies

1.10

confidence

Rotenone

300+

studies

1.10

confidence

Antimycin A

300+

studies

1.10

confidence

Artemisia Capillaris

1.00

confidence

Bupleurum Chinense

1.00

confidence

Chaenomeles Speciosa

1.00

confidence

Agastache Rugosa

1.00

confidence

Allium Tuberosum

1.00

confidence

Aloe Vera

1.00

confidence

Apis Mellifera

1.00

confidence

Aster Tataricus

1.00

confidence

Crizotinib

298+

studies

0.69

confidence

Berberine

300+

studies

0.69

confidence

Metformin

1.0k+

studies

0.69

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: PRKAA1 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.