Compounds That Target SIRT1

sirtuin 1 · 133 compounds in BiohacksAI corpus

SIRT1 (sirtuin 1) is an NAD⁺-dependent deacetylase central to longevity, metabolic regulation, and DNA repair. As one of the most studied targets in aging research, SIRT1 is activated by caloric restriction and compounds such as resveratrol and NAD⁺ precursors. It regulates key transcription factors including PGC-1α, FOXO, and NF-κB, linking energy metabolism to lifespan extension. The 133 compounds listed here have documented interactions with SIRT1 based on BindingDB binding assay data and PubMed literature evidence.