BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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Compounds That Target TLR4

toll-like receptor 4 · 121 compounds in BiohacksAI corpus

TLR4 (toll-like receptor 4) is a biological target with 121 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into TLR4 modulation for therapeutic and biohacking applications.

Most Studied Compounds for TLR4
500+
studies
500+
studies
499+
studies
300+
studies
299+
studies
298+
studies
289+
studies
26+
studies
All 50 Compounds — Ranked by Evidence
1
Methotrexate
6.00
confidence
26+
studies
1.79
confidence
298+
studies
1.10
confidence
289+
studies
1.10
confidence
5
Achyranthes Bidentata
1.00
confidence
6
Agastache Rugosa
1.00
confidence
500+
studies
1.00
confidence
8
Allium Tuberosum
1.00
confidence
9
Aloe Vera
1.00
confidence
10
Apis Mellifera
1.00
confidence
11
Arctium Lappa
1.00
confidence
12
Artemisia Argyi
1.00
confidence
13
Artemisia Capillaris
1.00
confidence
14
Aster Tataricus
1.00
confidence
15
Atractylodes Macrocephala
1.00
confidence
16
Bombyx Mori
1.00
confidence
17
Bupleurum Chinense
1.00
confidence
18
Carthamus Tinctorius
1.00
confidence
499+
studies
1.00
confidence
20
Chaenomeles Speciosa
1.00
confidence
21
Citrus Reticulata
1.00
confidence
22
Commiphora Myrrha
1.00
confidence
500+
studies
1.00
confidence
24
Cuscuta Chinensis
1.00
confidence
25
Cynomorium Songaricum
1.00
confidence
26
Ephedra Sinica
1.00
confidence
27
Eriobotrya Japonica
1.00
confidence
28
Eucommia Ulmoides
1.00
confidence
29
Forsythia Suspensa
1.00
confidence
30
Fritillaria Cirrhosa
1.00
confidence
31
Gastrodia Elata
1.00
confidence
32
Gentiana Macrophylla
1.00
confidence
299+
studies
1.00
confidence
34
Glycyrrhiza Uralensis
1.00
confidence
35
Ligusticum Chuanxiong
1.00
confidence
36
Lilium Lancifolium
1.00
confidence
37
Litchi Chinensis
1.00
confidence
38
Lithospermum Erythrorhizon
1.00
confidence
39
Lobelia Chinensis
1.00
confidence
40
Lonicera Japonica
1.00
confidence
41
Morus Alba
1.00
confidence
1.00
confidence
43
Paeonia Lactiflora
1.00
confidence
300+
studies
1.00
confidence
45
Panax Notoginseng
1.00
confidence
46
Perilla Frutescens
1.00
confidence
47
Pinellia Ternata
1.00
confidence
1.00
confidence
49
Polygala Tenuifolia
1.00
confidence
50
Polygonum Cuspidatum
1.00
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for TLR4 (toll-like receptor 4). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: TLR4 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.