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BiohacksAI/Pathways/Circadian Rhythm
PATHWAYCellular Defense

Circadian Rhythm

Biological clock regulation — disruption accelerates aging, affects metabolism and DNA repair

1,135 compounds · BiohacksAI corpus

1,135
compounds
Compounds
1,135
Category
Cellular Defense
Pathway ID
CIRCADIAN
MeSH Terms
Circadian RhythmCLOCK ProteinsPeriod Circadian RegulatorCryptochromeMelatoninBiological Clocks
Top Compounds — Circadian Rhythm (50 of 1,135)
1
Metformin
1,000
studies
73.4
evidence
2
Ibuprofen
1,000
studies
78.8
evidence
3
Fluoxetine
1,000
studies
75.8
evidence
4
Liraglutide
999
studies
76.7
evidence
5
Amlodipine
1,000
studies
75.7
evidence
6
Losartan
1,000
studies
75.0
evidence
7
Metoprolol
1,000
studies
75.7
evidence
8
Budesonide
1,000
studies
80.1
evidence
9
Sertraline
1,000
studies
76.2
evidence
10
Venlafaxine
1,000
studies
74.1
evidence
11
Salbutamol
297
studies
76.1
evidence
12
Insulin
1,000
studies
70.5
evidence
13
Prednisolone
1,000
studies
79.5
evidence
14
Naproxen
1,000
studies
74.8
evidence
15
Ciprofloxacin
1,000
studies
73.7
evidence
16
Tramadol
1,000
studies
77.9
evidence
17
Diazepam
999
studies
73.0
evidence
18
Empagliflozin
996
studies
73.3
evidence
19
Pregabalin
996
studies
77.1
evidence
20
Escitalopram
995
studies
74.8
evidence
21
Levothyroxine
994
studies
64.3
evidence
22
Quetiapine
994
studies
73.6
evidence
23
Duloxetine
993
studies
73.0
evidence
24
Sitagliptin
990
studies
72.1
evidence
25
Montelukast
985
studies
69.1
evidence
26
Lisinopril
904
studies
68.6
evidence
27
Glycine
300
studies
54.6
evidence
28
Dha
300
studies
62.2
evidence
29
Tryptophan
300
studies
55.5
evidence
30
Bacopa_monnieri
507
studies
40.8
evidence
31
Vitamin_c
503
studies
60.8
evidence
32
Neuropeptide_y
500
studies
44.2
evidence
33
Cucumis_sativus
500
studies
40.0
evidence
34
Cynodon_dactylon
500
studies
40.5
evidence
35
Prunus_avium
500
studies
42.2
evidence
36
Zinc
297
studies
58.1
evidence
37
Cajanus_cajan
500
studies
39.9
evidence
38
Cucumis_melo
500
studies
41.4
evidence
39
Eucalyptus_globulus
500
studies
39.6
evidence
40
Galanin
500
studies
43.1
evidence
41
Azadirachta_indica
500
studies
37.0
evidence
42
Brassica_campestris
500
studies
40.0
evidence
43
Citrus_limon
500
studies
39.0
evidence
44
Hibiscus_sabdariffa
500
studies
41.3
evidence
45
Lepidium_sativum
500
studies
36.5
evidence
46
Saccharum_officinarum
500
studies
42.1
evidence
47
Solanum_nigrum
500
studies
36.7
evidence
48
Trigonella_foenum
499
studies
39.0
evidence
49
Glutathione
300
studies
56.9
evidence
50
Hordeum_vulgare
499
studies
39.9
evidence

Data from PubMed, BindingDB, and Reactome. Not medical advice.