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BiohacksAI/Pathways/HPA Axis / Stress Response
PATHWAYHormonal

HPA Axis / Stress Response

Hypothalamic-pituitary-adrenal axis — chronic stress accelerates aging via cortisol

2,665 compounds · BiohacksAI corpus

2,665
compounds
Compounds
2,665
Category
Hormonal
Pathway ID
CORTISOL_STRESS
MeSH Terms
Hypothalamo-Hypophyseal SystemPituitary-Adrenal SystemAdrenocorticotropic HormoneCorticotropin-Releasing HormoneStress, PhysiologicalStress, PsychologicalGlucocorticoidsHydrocortisone
Top Compounds — HPA Axis / Stress Response (50 of 2,665)
1
Prednisolone
1,000
studies
79.5
evidence
2
Budesonide
1,000
studies
80.1
evidence
3
Rituximab
1,000
studies
74.1
evidence
4
Salbutamol
297
studies
76.1
evidence
5
Insulin
1,000
studies
70.5
evidence
6
Ciprofloxacin
1,000
studies
73.7
evidence
7
Sertraline
1,000
studies
76.2
evidence
8
Fluoxetine
1,000
studies
75.8
evidence
9
Venlafaxine
1,000
studies
74.1
evidence
10
Aspirin
1,000
studies
69.5
evidence
11
Ibuprofen
1,000
studies
78.8
evidence
12
Paracetamol
1,000
studies
77.1
evidence
13
Simvastatin
1,000
studies
73.6
evidence
14
Azithromycin
1,000
studies
78.3
evidence
15
Warfarin
1,000
studies
65.0
evidence
16
Losartan
1,000
studies
75.0
evidence
17
Tramadol
1,000
studies
77.9
evidence
18
Metformin
1,000
studies
73.5
evidence
19
Metoprolol
1,000
studies
75.7
evidence
20
Naproxen
1,000
studies
74.8
evidence
21
Amlodipine
1,000
studies
75.7
evidence
22
Amoxicillin
1,000
studies
79.4
evidence
23
Atorvastatin
1,000
studies
76.1
evidence
24
Pembrolizumab
1,000
studies
73.3
evidence
25
Trastuzumab
1,000
studies
75.4
evidence
26
Diazepam
999
studies
73.0
evidence
27
Doxycycline
999
studies
76.8
evidence
28
Liraglutide
999
studies
76.7
evidence
29
Enoxaparin
998
studies
76.4
evidence
30
Pregabalin
996
studies
77.1
evidence
31
Escitalopram
995
studies
74.8
evidence
32
Levothyroxine
994
studies
64.3
evidence
33
Quetiapine
994
studies
73.6
evidence
34
Duloxetine
993
studies
73.0
evidence
35
Sitagliptin
990
studies
72.1
evidence
36
Montelukast
985
studies
69.1
evidence
37
Lisinopril
904
studies
68.6
evidence
38
Neuropeptide_y
500
studies
44.2
evidence
39
Cucumis_sativus
500
studies
40.0
evidence
40
Ocimum_sanctum
500
studies
38.1
evidence
41
Brassica_campestris
500
studies
40.0
evidence
42
Cynodon_dactylon
500
studies
40.5
evidence
43
Galanin
500
studies
43.1
evidence
44
Nelumbo__nucifera
500
studies
39.5
evidence
45
Nelumbo_nucifera
500
studies
39.5
evidence
46
Cucumis_melo
500
studies
41.4
evidence
47
Oryza_sativa
500
studies
37.0
evidence
48
Sesamum_indicum
500
studies
41.6
evidence
49
Withania_somnifera
500
studies
37.6
evidence
50
Cajanus_cajan
500
studies
39.9
evidence

Data from PubMed, BindingDB, and Reactome. Not medical advice.