BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
BiohacksAI is an evolving scientific literature platform. New compounds and evidence are indexed continuously.
B
○
BiohacksAI/Pathways/Insulin / IGF-1 Signaling
PATHWAYGrowth Signaling

Insulin / IGF-1 Signaling

PI3K-AKT-FOXO axis — reduced signaling associated with longevity in model organisms

3,083 compounds · BiohacksAI corpus

3,083
compounds
Compounds
3,083
Category
Growth Signaling
Pathway ID
INSULIN_SIGNALING
MeSH Terms
InsulinInsulin ResistanceInsulin-Like Growth Factor IReceptor, InsulinProto-Oncogene Proteins c-aktPhosphatidylinositol 3-KinasesFOXO Transcription FactorsForkhead Transcription FactorsBlood GlucoseGlycated Hemoglobin
Top Compounds — Insulin / IGF-1 Signaling (50 of 3,083)
1
Metformin
1,000
studies
73.4
evidence
2
Ibuprofen
1,000
studies
78.8
evidence
3
Pembrolizumab
1,000
studies
73.3
evidence
4
Liraglutide
999
studies
76.7
evidence
5
Fluoxetine
1,000
studies
75.8
evidence
6
Rituximab
1,000
studies
74.1
evidence
7
Insulin
1,000
studies
70.5
evidence
8
Semaglutide
999
studies
69.9
evidence
9
Losartan
1,000
studies
75.0
evidence
10
Simvastatin
1,000
studies
73.6
evidence
11
Atorvastatin
1,000
studies
76.1
evidence
12
Metoprolol
1,000
studies
75.7
evidence
13
Amlodipine
1,000
studies
75.7
evidence
14
Salbutamol
297
studies
76.1
evidence
15
Prednisolone
1,000
studies
79.5
evidence
16
Sertraline
1,000
studies
76.2
evidence
17
Trastuzumab
1,000
studies
75.4
evidence
18
Aspirin
1,000
studies
69.5
evidence
19
Paracetamol
1,000
studies
77.1
evidence
20
Venlafaxine
1,000
studies
74.1
evidence
21
Ciprofloxacin
1,000
studies
73.7
evidence
22
Azithromycin
1,000
studies
78.3
evidence
23
Budesonide
1,000
studies
80.1
evidence
24
Naproxen
1,000
studies
74.8
evidence
25
Tramadol
1,000
studies
77.9
evidence
26
Warfarin
1,000
studies
65.0
evidence
27
Amoxicillin
1,000
studies
79.4
evidence
28
Doxycycline
999
studies
76.8
evidence
29
Diazepam
999
studies
73.0
evidence
30
Empagliflozin
996
studies
73.3
evidence
31
Pregabalin
996
studies
77.1
evidence
32
Escitalopram
995
studies
74.8
evidence
33
Levothyroxine
994
studies
64.3
evidence
34
Quetiapine
994
studies
73.6
evidence
35
Duloxetine
993
studies
73.0
evidence
36
Sitagliptin
990
studies
72.1
evidence
37
Montelukast
985
studies
69.1
evidence
38
Lisinopril
904
studies
68.6
evidence
39
Alpha_linolenic_acid
518
studies
55.8
evidence
40
Glycine
300
studies
54.6
evidence
41
Dha
300
studies
62.2
evidence
42
Lysine
299
studies
51.2
evidence
43
Tryptophan
300
studies
55.5
evidence
44
Proline
300
studies
47.2
evidence
45
Curcumin
300
studies
58.0
evidence
46
Vitamin_b12
508
studies
60.4
evidence
47
Bacopa_monnieri
507
studies
40.8
evidence
48
Ribose
300
studies
54.5
evidence
49
Vitamin_c
503
studies
60.8
evidence
50
Epa
300
studies
64.5
evidence

Data from PubMed, BindingDB, and Reactome. Not medical advice.