What compounds affect the Neurotransmitter release cycle pathway?

100 compounds in the BiohacksAI corpus have documented interactions with genes in the Neurotransmitter release cycle pathway (Reactome ID: R-HSA-112310). These compounds target 13 genes within this pathway.

What genes are in the Neurotransmitter release cycle pathway?

The Neurotransmitter release cycle pathway involves 13 genes. Key genes include: ABAT, ALDH5A1, CASK, GLS, HSPA8, MAOA, SLC1A1, SLC1A2, SLC1A3, SLC22A1.

Neurotransmitter release cycle

REACTOME PATHWAY

Reactome: R-HSA-11231013 genes100 compounds

The Neurotransmitter release cycle pathway (Reactome ID: R-HSA-112310) involves 13 genes and is affected by 100 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABAT ALDH5A1 CASK GLS HSPA8 MAOA SLC1A1 SLC1A2 SLC1A3 SLC22A1 SLC5A7 SLC6A11 SLC6A12

Compounds Affecting Neurotransmitter release cycle

#	Compound	Targets Hit	Studies
1	Harmaline	—	300
2	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
3	Guanabenz	—	298
4	ethopropazine	—	17
5	Hexachlorophene	—	300
6	Aspartic Acid	—	300
7	Glutamic Acid	—	297
8	Glutamic Acid	—	300
9	gamma-Aminobutyric Acid	—	300
10	Valproic Acid	—	296
11	Iproniazid	—	300
12	Moclobemide	—	299
13	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	Quercetin	—	300
16	Phenelzine	—	297
17	Genistein	—	300
18	Idazoxan	—	300
19	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
20	hispidol	—	13
21	Linezolid	—	298
22	Vitamin K 3	—	300
23	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	—	300
24	chrysin	—	300
25	Methylene Blue	—	200
26	plumbagin [Supplementary Concept]	—	300
27	Sirolimus	—	300
28	Rutin	—	300
29	Aripiprazole	—	298
30	auraptene	—	148
31	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
32	Famotidine	—	296
33	Fentanyl	—	300
34	Guanfacine	—	294
35	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
36	Lynestrenol	—	299
37	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
38	pentamidine	—	299
39	Rilmenidine Oxazole derivative that acts as	—	300
40	Sorafenib	—	300
41	caffeic acid	—	300
42	Resveratrol	—	298
43	2-Methoxyestradiol	—	300
44	ag490	—	14
45	alpha-Linolenic Acid	—	300
46	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
47	Calcimycin	—	216
48	cefaclor	—	299
49	cefatrizine	—	114
50	Cefixime	—	300

About the Neurotransmitter release cycle Pathway

The Neurotransmitter release cycle pathway is catalogued in Reactome (ID: R-HSA-112310) and involves 13 genes. In the BiohacksAI corpus, 100 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABAT, ALDH5A1, CASK, GLS, HSPA8.