What compounds affect the Activation of BH3-only proteins pathway?

158 compounds in the BiohacksAI corpus have documented interactions with genes in the Activation of BH3-only proteins pathway (Reactome ID: R-HSA-114452). These compounds target 7 genes within this pathway.

What genes are in the Activation of BH3-only proteins pathway?

The Activation of BH3-only proteins pathway involves 7 genes. Key genes include: AKT3, BAD, BCL2L11, MAPK8, TP53, YWHAB, YWHAG.

Activation of BH3-only proteins

REACTOME PATHWAY

Reactome: R-HSA-1144527 genes158 compounds

The Activation of BH3-only proteins pathway (Reactome ID: R-HSA-114452) involves 7 genes and is affected by 158 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 BAD BCL2L11 MAPK8 TP53 YWHAB YWHAG

Compounds Affecting Activation of BH3-only proteins

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Axitinib	—	298
3	Idarubicin	—	299
4	sp600125	—	117
5	Anisomycin	—	247
6	Ethidium	—	300
7	Ethinyl Estradiol	—	300
8	Hexachlorophene	—	300
9	Azacitidine	—	298
10	Azacitidine	—	300
11	Methylene Blue	—	200
12	Bortezomib	—	300
13	Rotenone	—	300
14	Azathioprine	—	300
15	Cladribine	—	297
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
18	Cytarabine	—	297
19	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
20	Melphalan	—	300
21	Niclosamide	—	299
22	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
23	Methotrexate	—	289
24	Dactinomycin	—	297
25	Daunorubicin	—	298
26	Disulfiram	—	297
27	Glutaral	—	42
28	Vitamin K 3	—	300
29	Trifluridine	—	295
30	ninhydrin	—	300
31	o-Phthalaldehyde	—	300
32	Razoxane	—	154
33	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
34	plumbagin [Supplementary Concept]	—	300
35	Camptothecin	—	300
36	Reserpine	—	297
37	Genistein	—	300
38	Resveratrol	—	298
39	Ciclopirox	—	88
40	Clofarabine	—	298
41	cycloheximide	—	300
42	daph	—	2
43	Dinitrochlorobenzene	—	300
44	Estramustine	—	300
45	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
46	Loratadine	—	296
47	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
48	Riluzole	—	298
49	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242
50	Trabectedin	—	297

About the Activation of BH3-only proteins Pathway

The Activation of BH3-only proteins pathway is catalogued in Reactome (ID: R-HSA-114452) and involves 7 genes. In the BiohacksAI corpus, 158 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, BAD, BCL2L11, MAPK8, TP53.